1,2-Dibromo-4-fluorobenzene

Base Information

• Chemical Name: 1,2-Dibromo-4-fluorobenzene
• CAS No.: 2369-37-1
• Molecular Formula: C6H3Br2F
• Molecular Weight: 253.896
• Hs Code.: 2903999090
• European Community (EC) Number: 219-131-1
• UNII: GT2BM2GZF4
• DSSTox Substance ID: DTXSID60178355
• Nikkaji Number: J213.226E
• Wikidata: Q72464336
• Mol file: 2369-37-1.mol

Synonyms:3,4-DIBROMOFLUOROBENZENE;1,2-DIBROMO-4-FLUOROBENZENE;1,2-Dibromo-4-fluorobenzene,98%;1,2-Dibromo-4-fluorobenzene 99%;1,2-Dibromo-4-fluorobenzene99%;3,4-Dibromo-1-fluorobenzene;1,2-DibroMo-4-fluorobenzene[3,4-DibroMofluorobenzene]

Chemical Property of 1,2-Dibromo-4-fluorobenzene

Chemical Property:

• Appearance/Colour: Clear colourless to light yellow liquid
• Melting Point: 69 °C
• Refractive Index: 1.5780-1.5820
• Boiling Point: 219.7 °C at 760 mmHg
• Flash Point: 86.7 °C
• PSA: 0.00000
• Density: 2.015 g/cm³
• LogP: 3.35070
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 253.85650
• Heavy Atom Count: 9
• Complexity: 97.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,2-Dibromo-4-fluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1F)Br)Br

Technology Process of 1,2-Dibromo-4-fluorobenzene

There total 7 articles about 1,2-Dibromo-4-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

→ 1,2,-dibromo-4-fluorobenzene (2369-37-1)

Guidance literature:

With bromine; dibromoisocyanuric acid; In dichloromethane; at 20 ℃; for 24h; UV-irradiation;

Reference yield:

fluorobenzene (462-06-6) → 1,2,-dibromo-4-fluorobenzene (2369-37-1) + 2,4-dibromo-1-fluorobenzene (1435-53-6) + 1-Bromo-4-fluorobenzene (460-00-4)

Guidance literature:

DOI:10.1021/ja01847a069

Reference yield:

bromine (7726-95-6) + 1-Bromo-4-fluorobenzene (460-00-4) → 1,2,-dibromo-4-fluorobenzene (2369-37-1) + 2,4-dibromo-1-fluorobenzene (1435-53-6)

Guidance literature:

upstream raw materials:

fluorobenzene

3,4-dibromoaniline

1-Bromo-4-fluorobenzene

4-fluoroaniline

Downstream raw materials:

dihydroxy-(5-bromo-2-fluorophenyl)-borane

4-fluorophthalonitrile

4-fluoro-1,2-bis(trimethylsilyl)benzene

1-bromo-4-fluoro-2-trimethylsilylbenzene

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF ORGANIC BROMIDES". Paragraph 00139; 00152. . Retrieved 2017/07/28.