N-[1-(4,4-diphenyl-butyl)-4-phenyl-piperidin-4-ylmethyl]-formamide

Base Information

• Chemical Name: N-[1-(4,4-diphenyl-butyl)-4-phenyl-piperidin-4-ylmethyl]-formamide
• CAS No.: 913370-83-9
• Molecular Formula: C₂₉H₃₄N₂O
• Molecular Weight: 426.602
• Mol file: 913370-83-9.mol

Synonyms:

Chemical Property of N-[1-(4,4-diphenyl-butyl)-4-phenyl-piperidin-4-ylmethyl]-formamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[1-(4,4-diphenyl-butyl)-4-phenyl-piperidin-4-ylmethyl]-formamide

There total 4 articles about N-[1-(4,4-diphenyl-butyl)-4-phenyl-piperidin-4-ylmethyl]-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-chloro-phenyl)-1-(4,4-diphenyl-butyl)-piperidine-4-carbonitrile (913370-89-5) → N-[1-(4,4-diphenyl-butyl)-4-phenyl-piperidin-4-ylmethyl]-formamide (913370-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / AlCl₃; LiAlH₄ / tetrahydrofuran / 0 - 20 °C

2: 0.08 h / 200 °C / 12901 Torr / microwave irradiation

With lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran;

DOI:10.1016/j.bmc.2006.06.054

Reference yield:

1,1-diphenyl-4-chlorobutane (3312-08-1) → N-[1-(4,4-diphenyl-butyl)-4-phenyl-piperidin-4-ylmethyl]-formamide (913370-83-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / sodium iodide; sodium carbonate / acetonitrile / Heating

2: 63 percent / AlCl₃; LiAlH₄ / tetrahydrofuran / 0 - 20 °C

3: 0.08 h / 200 °C / 12901 Torr / microwave irradiation

With lithium aluminium tetrahydride; aluminium trichloride; sodium carbonate; sodium iodide; In tetrahydrofuran; acetonitrile;

DOI:10.1016/j.bmc.2006.06.054

Reference yield:

4-cyano-4-phenylpiperidine hydrochloride (51304-58-6) → N-[1-(4,4-diphenyl-butyl)-4-phenyl-piperidin-4-ylmethyl]-formamide (913370-83-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / sodium iodide; sodium carbonate / acetonitrile / Heating

2: 63 percent / AlCl₃; LiAlH₄ / tetrahydrofuran / 0 - 20 °C

3: 0.08 h / 200 °C / 12901 Torr / microwave irradiation

With lithium aluminium tetrahydride; aluminium trichloride; sodium carbonate; sodium iodide; In tetrahydrofuran; acetonitrile;

DOI:10.1016/j.bmc.2006.06.054

upstream raw materials:

C-[1-(4,4-diphenyl-butyl)-4-phenyl-piperidin-4-yl]-methylamine

formic acid

4-(4-chloro-phenyl)-1-(4,4-diphenyl-butyl)-piperidine-4-carbonitrile

1,1-diphenyl-4-chlorobutane

Refernces