17β-acetoxy-5β-estran-3-one

Base Information

• Chemical Name: 17β-acetoxy-5β-estran-3-one
• CAS No.: 2302-77-4
• Molecular Formula: C₂₀H₃₀O₃
• Molecular Weight: 318.456
• Mol file: 2302-77-4.mol

Synonyms:

Chemical Property of 17β-acetoxy-5β-estran-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 17β-acetoxy-5β-estran-3-one

There total 11 articles about 17β-acetoxy-5β-estran-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

19-nortestosterone acetate (1425-10-1) → 17β-acetoxy-5α-estran-3-one (33767-87-2) + 17β-acetoxy-5β-estran-3-one (2302-77-4)

Guidance literature:

With hydrogen; palladium; In pyridine; at 25 ℃; under 760 Torr; Rate constant; selectivity to 5β compound;

DOI:10.1246/bcsj.56.780

Reference yield:

17β-acetoxy-6α-fluoro-4-estren-3-one (3801-28-3) → 17β-acetoxy-5α-estran-3-one (33767-87-2) + 17β-acetoxy-5β-estran-3-one (2302-77-4) + 17β-acetoxy-6α-fluoro-5α-estran-3-one + 17β-acetoxy-6α-fluoro-5β-estran-3-one

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 1.5h; Title compound not separated from byproducts; Ambient temperature;

DOI:10.1016/0039-128X(95)00009-F

Reference yield:

17β-hydroxyestr-4-en-3-one 17-acetate (1425-10-1) → 17β-Acetoxy-3-oxo-19-nor-androstan (2302-77-4,5138-34-1,22960-89-0,33767-87-2,95529-49-0,102489-88-3,102489-89-4)

Guidance literature:

With hydrogen bromide; hydrogen; palladium; In tetrahydrofuran; Product distribution; Ambient temperature; atmospheric pressure // various nitrogen bases uesd instead of HBr/THF;

DOI:10.1021/jo01301a043

upstream raw materials:

17β-hydroxyestr-4-en-3-one 17-acetate

19-nortestosterone

19-nortestosterone acetate

17β-acetoxy-6α-fluoro-4-estren-3-one

Refernces

• 1、 Nishimura, Shigeo,Momma, Yasuhiro,Kawamura, Hideo,Shiota, Michio. "Stereochemistry of the Palladium-catalyzed Hydrogenation of 3-Oxo-4-ene Steroids. V. A Kinetic Study in Basic and Acidic Media". . p. 780 - 783. Retrieved 2007/10/02.