4,5α-epoxy-3,6-dimethoxy-morphina-6,8(14)-diene; salicylate

Base Information

• Chemical Name: 4,5α-epoxy-3,6-dimethoxy-morphina-6,8(14)-diene; salicylate
• CAS No.: 3889-83-6
• Molecular Formula: C₇H₆O₃*C₁₈H₁₉NO₃
• Molecular Weight: 435.477
• Mol file: 3889-83-6.mol

Synonyms:

Chemical Property of 4,5α-epoxy-3,6-dimethoxy-morphina-6,8(14)-diene; salicylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5α-epoxy-3,6-dimethoxy-morphina-6,8(14)-diene; salicylate

There total 13 articles about 4,5α-epoxy-3,6-dimethoxy-morphina-6,8(14)-diene; salicylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Norhydrocodone (5083-62-5) → 4,5α-epoxy-3,6-dimethoxy-morphina-6,8(14)-diene; salicylate (3889-83-6)

Guidance literature:

Multi-step reaction with 7 steps

1: MgO / H₂O; dioxane

2: NaOtBu / 2-methyl-propan-2-ol

3: Br₂, MgO / CHCl₃

4: K, 2-methyl-butan-2-ol / toluene / Heating

5: TsOH / CHCl₃

6: TsOH

7: diethyl ether

With tert-Amyl alcohol; bromine; magnesium oxide; toluene-4-sulfonic acid; sodium t-butanolate; In 1,4-dioxane; diethyl ether; chloroform; water; toluene; tert-butyl alcohol;

DOI:10.1039/j39660000617

Reference yield:

4,5α-epoxy-3-methoxy-morphin-7-en-6ξ-ol (467-15-2,10118-79-3,25318-90-5,131830-12-1) → 4,5α-epoxy-3,6-dimethoxy-morphina-6,8(14)-diene; salicylate (3889-83-6)

Guidance literature:

Multi-step reaction with 8 steps

1: KOtBu, Ph₂CO / benzene

2: MgO / H₂O; dioxane

3: NaOtBu / 2-methyl-propan-2-ol

4: Br₂, MgO / CHCl₃

5: K, 2-methyl-butan-2-ol / toluene / Heating

6: TsOH / CHCl₃

7: TsOH

8: diethyl ether

With benzophenone; tert-Amyl alcohol; potassium tert-butylate; bromine; magnesium oxide; toluene-4-sulfonic acid; sodium t-butanolate; In 1,4-dioxane; diethyl ether; chloroform; water; toluene; tert-butyl alcohol; benzene;

DOI:10.1039/j39660000617

Reference yield:

N-t-butoxycarbonyl-N-northebaine (2668-48-6) → 4,5α-epoxy-3,6-dimethoxy-morphina-6,8(14)-diene; salicylate (3889-83-6)

Guidance literature:

Multi-step reaction with 2 steps

1: TsOH

2: diethyl ether

With toluene-4-sulfonic acid; In diethyl ether;

DOI:10.1039/j39660000617

upstream raw materials:

northebaine

salicylic acid

Norhydrocodone

7ξ-bromo-4,5α-epoxy-3,6,6-trimethoxy-morphinane