5083-62-5Relevant articles and documents
ANTI-OPIOID VACCINES
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Page/Page column 14, (2018/05/24)
The invention provides haptens and methods of preparation thereof, for producing immunoconjugates of oxycodone and hydrocodone suitable for raising antibodies in animals specific for the opioid drugs. Adminislration of the opioid-speeific antibodies to humans having the opioid drugs in a body fluid such as blood serum, binds the opioid drugs to the antibody, making the opioids unavailable for producing a drug effect. Accordingly the antibodies can be used to reverse the effects of a drug overdose of oxycodone and hydrocodone, or to reverse a perceived mental effect of the. drugs, such as euphoria.
METHODS FOR N-DEMETHYLATION OF MORPHINE AND TROPANE ALKALOIDS
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Page/Page column 3, (2009/01/24)
The present invention provides a method for the N-demethylation of an N-methylated heterocycle, particularly a morphine or tropane alkaloid or derivative thereof. The method comprises reacting the heterocycle with a metal catalyst and a solvent in the presence of an oxidizing agent.
14,17-Cyclonorcodeinone dimethylacetal: A New Codeinon Derivative, II
Fleischhacker, W.,Richter, B.,Voellenkle, H.
, p. 399 - 411 (2007/10/02)
In addition to a short communication describing the synthesis of 14,17-cyclonorcodeinone dimethylacetal 1a we wish to present a simple alternative route together with a selection of some reactions depending on the great reactivity of this highly strained small ring system.The structure of 1a is established by X-ray analysis.
