845-69-2 Usage
Description
Nordihydrocodeine, also known as a metabolite of Dihydrocodeine (D448850), is a controlled substance with specific applications in various industries. It is derived from the metabolism of Dihydrocodeine, a semi-synthetic opioid analgesic used for pain management.
Uses
Used in Pharmaceutical Industry:
Nordihydrocodeine is used as an active pharmaceutical ingredient for the development of pain relief medications. It is utilized in the formulation of drugs that target the management of moderate to severe pain, providing an alternative to other opioid analgesics.
Used in Research and Development:
In the field of pharmaceutical research and development, nordihydrocodeine serves as a key compound for studying the metabolism and pharmacokinetics of Dihydrocodeine. This helps in understanding the drug's efficacy, safety, and potential side effects, ultimately contributing to the improvement of pain management therapies.
Used in Regulatory Compliance:
As a controlled substance, nordihydrocodeine is used in regulatory compliance and monitoring efforts to ensure the responsible distribution, prescription, and use of opioid analgesics. This helps in preventing the misuse and abuse of these potent pain relievers, safeguarding public health and addressing the ongoing opioid crisis.
Used in Toxicology and Forensic Analysis:
Nordihydrocodeine plays a role in toxicology and forensic analysis, where it is identified and quantified in biological samples to determine the presence and levels of Dihydrocodeine and its metabolites. This is crucial in cases of drug overdose, poisoning, or substance abuse investigations, aiding in the legal and medical assessment of such incidents.
Check Digit Verification of cas no
The CAS Registry Mumber 845-69-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,4 and 5 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 845-69:
(5*8)+(4*4)+(3*5)+(2*6)+(1*9)=92
92 % 10 = 2
So 845-69-2 is a valid CAS Registry Number.
InChI:InChI=1/C17H21NO3/c1-20-13-5-2-9-8-11-10-3-4-12(19)16-17(10,6-7-18-11)14(9)15(13)21-16/h2,5,10-12,16,18-19H,3-4,6-8H2,1H3/t10?,11-,12+,16?,17+/m1/s1
845-69-2Relevant articles and documents
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Perrine,Small
, p. 111 (1956)
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PROCESS FOR REDUCING THE 6-KETO GROUP OF A MORPHINAN ALKALOID TO THE 6-HYDROXY GROUP BY HYDROGENATION
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Page/Page column 4-5, (2011/04/13)
The present invention relates to a process for the reduction of a 6-keto group in a morphinan alkaloid to the corresponding 6-hydroxy group, comprising hydrogenating the 6-keto group using gaseous hydrogen in the presence of a heterogeneous catalyst and a solvent, to yield the 6-hydroxy morphinan alkaloid, wherein the reduction is carried out at a pH in the range of about 5 to about 7, and the 6-hydroxy morphinan alkaloid has an α:β ratio of > 85: 15.
Metabolism and pharmacokinetics of dihydrocodeine in dog
Konishi,Shiono,Ohno,Takahashi,Aoki
, p. 591 - 601 (2007/10/03)
The metabolism and pharmacokinetics of dihydrocodeine have been studied in dog. Urinary metabolites after oral administration of dihydrocodeine were identified using hplc with diode-array and ms. In urine, dihydronorcodeine, dihydromorphine and dihydrocodeine glucuronide were identified in comparison with their authentic standards, and dihydronorcodeine 6-glucuronide also appeared to be excreted as a metabolite. The major urinary metabolite was dihydrocodeine glucuronide, recovered as 49% of the dose, and other metabolites were found to be 0.1-3%, 24h after 3 mg/kg oral administration of dihydrocodeine. Plasma concentrations of unchanged dihydrocodeine were significantly lower after oral rather than intramuscular administration, the maximum concentrations were 40 and 549 ng/ml after oral and intramuscular administration, respectively. This suggests that dihydrocodeine was metabolized via a hepatic first-pass effect after oral administration. Overall, our results indicate that the metabolic pathways of dihydrocodeine in dog were similar to that of codeine metabolism in animals and man.
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