3861-72-1Relevant articles and documents
Synthesis of 1-fluoro-substituted codeine derivatives
Hosztafi, Sándor,Marton, János
, p. 973 - 982 (2016)
Syntheses of new N-demethyl-N-substituted analogues (propyl, allyl) of 1-fluorocodeine and their 7,8-dihydro derivatives were described starting from codeine. 1-Fluoronorcodeine and 1-fluorodihydronorcodeine were prepared by N-demethylation with α-chloroethyl chloroformate from the corresponding 6-O-acetyl protected derivatives. 3-O-Demethylation of 1-fluorocodeine and 1-fluorodihydrocodeine with boron tribromide resulted in 1-fluoromorphine and 1-fluorodihydromorphine respectively. 1-Fluorodihydromorphine was acetylated to 3,6-di-O-acetyl-1-fluorodihydromorphine. 8-Fluoroapocodeine and N-propyl-8-fluoroapocodeine were synthesized from the appropriate 1-fluorocodeine derivatives by acid-catalyzed rearrangement.
On the identification of dihydrocodeine phosphate and its preparations
Asahina,Ono,Shimamine,Takahashi
, p. 18 - 21 (2007/10/10)
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