Technology Process of C52H67N11O13
There total 12 articles about C52H67N11O13 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: Et3N; DMAP / acetonitrile; H2O / 20 °C
1.2: 86 percent / K2CO3 / aq. methanol
2.1: Et3N; DMAP / toluene / Heating
2.2: 94 percent / MeOH / 20 °C
3.1: 89 percent / NaHMDS / N,N-dimethyl-acetamide / Heating
4.1: 98 percent / DBU / CH2Cl2
5.1: H2 / (R,R)-DlPAMP) rhodium(I) catalyst / ethanol / 80 °C / 3878.61 Torr
6.1: HCl / dioxane
7.1: HOAt; EDCl; Et3N / CH2Cl2
With
hydrogenchloride; dmap; 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium hexamethyldisilazane; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
(R,R)-DlPAMP) rhodium(I) catalyst;
In
1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl acetamide; water; toluene; acetonitrile;
4.1: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/S0040-4039(03)01258-9
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 85 percent / K2CO3; NaI / acetone
2: 89 percent / NaHMDS / N,N-dimethyl-acetamide / Heating
3: 98 percent / DBU / CH2Cl2
4: H2 / (R,R)-DlPAMP) rhodium(I) catalyst / ethanol / 80 °C / 3878.61 Torr
5: HCl / dioxane
6: HOAt; EDCl; Et3N / CH2Cl2
With
hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium hexamethyldisilazane; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium iodide;
(R,R)-DlPAMP) rhodium(I) catalyst;
In
1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl acetamide; acetone;
3: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/S0040-4039(03)01258-9
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 85 percent / K2CO3; NaI / acetone
2: 89 percent / NaHMDS / N,N-dimethyl-acetamide / Heating
3: 98 percent / DBU / CH2Cl2
4: H2 / (R,R)-DlPAMP) rhodium(I) catalyst / ethanol / 80 °C / 3878.61 Torr
5: HCl / dioxane
6: HOAt; EDCl; Et3N / CH2Cl2
With
hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium hexamethyldisilazane; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium iodide;
(R,R)-DlPAMP) rhodium(I) catalyst;
In
1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl acetamide; acetone;
3: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/S0040-4039(03)01258-9