1596-64-1 Usage
Description
L-(-)-Histidinol dihydrochloride, also known as L-Histidinol, is a natural amino alcohol that acts as an intermediate in the biosynthesis of the amino acid L-histidine in various organisms, including bacteria, archaebacteria, fungi, and plants. It is derived from its precursor, L-histidinol phosphate, through the action of a phosphatase enzyme. L-(-)-Histidinol dihydrochloride is characterized by its white to slightly beige crystalline powder appearance.
Uses
1. Used in Pharmaceutical Industry:
L-(-)-Histidinol dihydrochloride is used as a key intermediate for the synthesis of L-histidine, which is an essential amino acid for the proper functioning of the human body. It plays a crucial role in the production of histamine, which is involved in immune responses, and the synthesis of other important biomolecules.
2. Used in Research and Development:
L-(-)-Histidinol dihydrochloride is utilized as a research compound in the study of histidine metabolism and its related pathways. It helps researchers understand the biochemical processes and mechanisms involved in the biosynthesis of L-histidine and its role in various cellular functions.
3. Used in Biochemical Assays:
L-(-)-Histidinol dihydrochloride serves as a substrate or standard in various biochemical assays and analytical procedures, allowing for the accurate measurement and quantification of enzymes and other proteins involved in histidine metabolism.
4. Used in Nutritional Supplements:
L-(-)-Histidinol dihydrochloride can be used as an additive in nutritional supplements, particularly those aimed at supporting immune function and overall health, due to its role in the synthesis of histamine and other essential biomolecules.
5. Used in Drug Development:
L-(-)-Histidinol dihydrochloride may be employed in the development of new drugs targeting histidine metabolism or related pathways, potentially leading to novel therapeutics for various diseases and conditions.
in vitro
preliminary experiments were done to investigate the cytotoxic effect of l-histidinol on cultured eac cells. results showed that l-histidinol up to 4 mm had no cytotoxic effects on eac cells. doxorubicin alone showed concentration-dependent cytotoxic effects. l-histidinol combination with doxorubicin led to significant potentiation of doxorubicin cytotoxicity to eac cells compared to doxorubicin alone. the concentration that caused 50% growth inhibition in eac cells after 24 h incubation was about 0.2 μg/ml, whereas it was 0.1 μg/ml when l-histidinol was added to culture medium [1].
in vivo
l-histidinol at 250 mg/kg for five consecutive doses before doxorubicin single injection could enhance the antitumour activity of doxorubicin in eac-bearing mice as demonstrated by a significant increase in average life span and cure rate of mice. in normal mice, l-histidinol, in the same dose regimen, could not alter the acute cardiotoxicity and lethality of doxorubicin [1].
references
[1] al-shabanah oa, badary oa, al-gharably nm, al-sawaf ha. effects of l-histidinol on the antitumour activity and acute cardiotoxicity of doxorubicin in mice. pharmacol res. 1998 sep;38(3):225-30.
Check Digit Verification of cas no
The CAS Registry Mumber 1596-64-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,5,9 and 6 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1596-64:
(6*1)+(5*5)+(4*9)+(3*6)+(2*6)+(1*4)=101
101 % 10 = 1
So 1596-64-1 is a valid CAS Registry Number.
1596-64-1Relevant articles and documents
COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS
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Page/Page column 45-49; 58, (2010/12/31)
The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.
Synthesis and in vitro pharmacology of a series of new chiral histamine H3-receptor ligands: 2-(R and S)-amino-3-(1H-imidazol-4(5)-yl)propyl ether derivatives
Kovalainen, Jari T.,Christiaans, Johannes A. M.,Kotisaari, Sanna,Laitinen, Jarmo T.,M?nnist?, Pekka T.,Tuomisto, Leena,Gynther, Jukka
, p. 1193 - 1202 (2007/10/03)
To investigate stereospecificity and the mechanism of activation of the histamine H3-receptor, a series of 2-(R and S)-amino-3-(1H-imidazol-4(5)- yl)propyl ether derivatives were synthesized. In these compounds, the structures of the well-known antagonist iodoproxyfan and the full agonists R- or S-(α)-methylhistamine were combined in one molecule. The obtained 'hybrid' molecules were tested for H3-receptor affinity on rat cerebral cortex. Some selected compounds were further screened for H3-receptor functional activity with GTPγ[35S] autoradiography studies using rat brain tissue sections. The affinity of all the synthesized compounds (-log K(i) = 5.9-7.9) was lower than that found for iodoproxyfan or two of its analogues; however, the compounds showed stereospecificity. The S-configuration of the series of 2-amino-3-(1H-imidazol-4(5)-yl)propyl ether derivatives, which resembles the stereochemistry of R-(α)-methylhistamine, was more favorable. Incorporation of an amino group in the propyl chain of iodoproxyfan and analogues did not alter the antagonistic behavior for compounds with an aromatic side chain. However, when also the aromatic moiety was replaced by a cyclohexyl group, the compounds behaved as agonists. This indicates that an interaction between the side chain amino group and the H3-receptor protein is involved in H3-receptor activation. The 2-(S)-amino-3-(1H-imidazol-4(5)- yl)propyl cyclohexylmethyl ether (23) has H3-receptor agonistic properties with high affinity for the histamine H3-receptor (-log K(i) = 7.9 ± 0.2) and might serve as a useful tool for further studies concerning drug design and receptor-ligand interactions.
