(1-Chloroethyl)cyclopropane

Base Information

• Chemical Name: (1-Chloroethyl)cyclopropane
• CAS No.: 10524-06-8
• Molecular Formula: C5H9Cl
• Molecular Weight: 104.579
• European Community (EC) Number: 959-587-5
• Mol file: 10524-06-8.mol

Synonyms:(1-chloroethyl)cyclopropane;10524-06-8;1-chloroethylcyclopropane;SCHEMBL5031022;OLLKVCSBIYCEAV-UHFFFAOYSA-N;AKOS009235586;AT29678;BS-33884;CS-0209842;EN300-98480

Chemical Property of (1-Chloroethyl)cyclopropane

Chemical Property:

• PSA: 0.00000
• LogP: 2.02370
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 1
• Exact Mass: 104.0392780
• Heavy Atom Count: 6
• Complexity: 47.9

Purity/Quality:

99% ^*data from raw suppliers

(1-Chloroethyl)cyclopropane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C1CC1)Cl

Technology Process of (1-Chloroethyl)cyclopropane

There total 6 articles about (1-Chloroethyl)cyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-cyclopropylethanol (765-42-4) → (±)-(1-chloroethyl)cyclopropane (10524-06-8)

Guidance literature:

With 1,1,1,3,3,3-hexachloro-propan-2-one; triphenylphosphine; for 0.75h; Ambient temperature;

DOI:10.1021/jo00177a008

Reference yield: 61.0%

1-cyclopropylethanol (765-42-4) → 1-chloro-3-pentene (16435-50-0) + (±)-(1-chloroethyl)cyclopropane (10524-06-8)

Guidance literature:

With N-chloro-succinimide; dimethylsulfide; In dichloromethane; at 20 ℃; for 62h;

DOI:10.1021/jo047822p

Reference yield:

Cyclopropyl methyl ketone (765-43-5) → (±)-(1-chloroethyl)cyclopropane (10524-06-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / lithium aluminum hydride / diethyl ether / Heating

2: 84 percent / hexachloroacetone, triphenylphosphine / 0.75 h / Ambient temperature

With lithium aluminium tetrahydride; 1,1,1,3,3,3-hexachloro-propan-2-one; triphenylphosphine; In diethyl ether;

DOI:10.1021/jo00177a008

upstream raw materials:

1-cyclopropylethanol

1-cyclopropylethanol

Cyclopropyl methyl ketone

Downstream raw materials:

1-(4-chlorophenyl)-2-cyclopropyl-1-propanol

1-(p-chlorophenyl)-2-cyclopropyl-2-methylethan-1-one

cyproconazol

2-(4-chlorophenyl)-3-cyclopropyl-1,2-butylene oxide

Refernces

• 1、 Kapras, Vojtech,Vyklicky, Vojtech,Budesinsky, Milos,Cisarova, Ivana,Vyklicky, Ladislav,Chodounska, Hana,Jahn, Ullrich. "Total Synthesis of ent-Pregnanolone Sulfate and Its Biological Investigation at the NMDA Receptor". supporting information. p. 946 - 949. Retrieved 2018/02/23.
• 2、 Hrubiec, Robert T.,Smith, Michael B.. "Regioselective Route to Sterically Hindered Cyclopropylcarbinyl Halides". . p. 431 - 435. Retrieved 2007/10/02.