2-Cyclopropylethanol

Base Information

• Chemical Name: 2-Cyclopropylethanol
• CAS No.: 2566-44-1
• Molecular Formula: C5H10O
• Molecular Weight: 86.1338
• Hs Code.: 2906199090
• European Community (EC) Number: 680-717-9
• NSC Number: 250975
• UNII: C66TB83XKK
• DSSTox Substance ID: DTXSID50180361
• Nikkaji Number: J1.089.824B
• Wikidata: Q72460806
• Mol file: 2566-44-1.mol

Synonyms:2-cyclopropylethanol;2566-44-1;Cyclopropaneethanol;2-Cyclopropylethan-1-Ol;2-cyclopropyl-ethanol;1-Cyclopropyl ethanol;C66TB83XKK;MFCD00040762;NSC-250975;Cyclopropaneethanol~(2-Hydroxyethyl)Cyclopropane;(2-HYDROXYETHYL)CYCLOPROPANE;NSC250975;2-cyclopropyl ethanol;2-cyclopropane ethanol;cyclopropylmethyl carbinol;UNII-C66TB83XKK;C(CO)C1CC1;2-Cyclopropylethanol, AldrichCPR;AMY3915;DTXSID50180361;PENTAERYTHRITOLTETRABENZOATE;AKOS009158390;CS-W016679;GS-6412;NSC 250975;PB24555;SY041938;FT-0600510;EN300-73771;A817963;Z826525694

Chemical Property of 2-Cyclopropylethanol

Chemical Property:

• Appearance/Colour: Colorless Liquid
• Vapor Pressure: 5.13mmHg at 25°C
• Refractive Index: 1.4355
• Boiling Point: 127.3 °C at 760 mmHg
• PKA: 15.16±0.10(Predicted)
• Flash Point: 42 °C
• PSA: 20.23000
• Density: 0.975 g/cm₃
• LogP: 0.77880
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform, Methanol
• Water Solubility.: Miscible with water.
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 86.073164938
• Heavy Atom Count: 6
• Complexity: 39.2

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Cyclopropylethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xn
• Statements: 10-36-22
• Safety Statements: 16-23-36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1CCO
• Uses: 2-Cyclopropylethanol is used to prepare (2-bromo-ethyl)-cyclopropane by reacting with phosphorus tribromide.

Technology Process of 2-Cyclopropylethanol

There total 17 articles about 2-Cyclopropylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.5%

Cyclopropanecarboxaldehyde (1489-69-6) → 1-cyclopropylethanol (2566-44-1)

Guidance literature:

With sodium tetrahydroborate; In diethyl ether; at 25 ℃; for 1.25h;

Reference yield: 84.0%

→ (5R,6R)-endo-3-(2-Cyclopropylethoxy)-4-(1-azabicyclo[3.2.1]octyl-6-oxy)-1,2,5-thiadiazole + 1-cyclopropylethanol (2566-44-1)

Guidance literature:

Reference yield: 84.0%

→ (5R,6R)- endo -3-(2-Cyclopropylethoxy)-4-(1-azabicyclo[3.2.1]octyl-6-oxy)-1,2,5-thiadiazole + 1-cyclopropylethanol (2566-44-1)

Guidance literature:

upstream raw materials:

homoalylic alcohol

diiodomethane

ethenylcyclopropane

ethyl 2-cyclopropyl acetate

Downstream raw materials:

(2-bromoethyl)cyclopropane

cyclopropylacetic acid

cyclopropanecarboxylic acid

2-cyclopropylacetaldehyde

Refernces

• 1、 Gosselin, Francis,Lau, Stephen,Nadeau, Christian,Trinh, Thao,O'Shea, Paul D.,Davies, Ian W.. "A practical synthesis of m-prostaglandin E synthase-1 inhibitor MK-7285". scheme or table. p. 7790 - 7797. Retrieved 2010/03/05.
• 2、 -. "2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents". . . Retrieved 2008/06/13.