BUTTPARK 51\02-40

Base Information

• Chemical Name: BUTTPARK 51\02-40
• CAS No.: 132766-76-8
• Molecular Formula: C₈H₇N₅O₂
• Molecular Weight: 205.176
• Mol file: 132766-76-8.mol

Synonyms:

Chemical Property of BUTTPARK 51\02-40

Chemical Property:

Purity/Quality:

(5-PYRIDIN-3-YL-TETRAZOL-2-YL)-ACETIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BUTTPARK 51\02-40

There total 4 articles about BUTTPARK 51\02-40 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3-(1H-tetrazol-5-yl)pyridine (3250-74-6,208264-85-1) + ethyl bromoacetate (105-36-2) → 5-(3-pyridyl)tetrazole-2-acetic acid (132766-76-8)

Guidance literature:

3-(1H-tetrazol-5-yl)pyridine; ethyl bromoacetate; With potassium hydroxide; In methanol; at 70 ℃;

With hydrogenchloride; In methanol; water; pH=2;

DOI:10.1071/CH14442

Reference yield:

3-(1H-tetrazol-5-yl)pyridine (3250-74-6,208264-85-1) → 5-(3-pyridyl)tetrazole-2-acetic acid (132766-76-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium ethanolate / ethanol

2: sodium hydroxide / tetrahydrofuran; water

With sodium ethanolate; sodium hydroxide; In tetrahydrofuran; ethanol; water;

DOI:10.1016/j.bmcl.2019.01.027

Reference yield:

ethyl 2-(5-(pyridin-3-yl)-2H-tetrazol-2-yl)acetate → 5-(3-pyridyl)tetrazole-2-acetic acid (132766-76-8)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water;

DOI:10.1016/j.bmcl.2019.01.027

upstream raw materials:

3-(1H-tetrazol-5-yl)pyridine

ethyl bromoacetate

pyridine-3-carbonitrile

Refernces

• 1、 Sharma, Swagat,Kozek, Krystian A.,Abney, Kristopher K.,Kumar, Sushil,Gautam, Nagsen,Alnouti, Yazen,David Weaver,Hopkins, Corey R.. "Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators". . p. 791 - 796. Retrieved 2019/02/06.