Technology Process of (4bR,13aS)-13a-Methoxy-5,6,7,8,9,10,11,12,13,13a-decahydro-4bH-cycloundeca[a]inden-14-one O-{3-[2-(3,5-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl}-oxime
There total 5 articles about (4bR,13aS)-13a-Methoxy-5,6,7,8,9,10,11,12,13,13a-decahydro-4bH-cycloundeca[a]inden-14-one O-{3-[2-(3,5-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl}-oxime which
guide to synthetic route it.
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synthetic route:
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118017-85-9
(4bR,13aS)-13a-Methoxy-5,6,7,8,9,10,11,12,13,13a-decahydro-4bH-cycloundeca[a]inden-14-one O-{3-[2-(3,5-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl}-oxime
- Guidance literature:
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Multi-step reaction with 5 steps
1: 39 percent / 12N HCl / acetone; H2O / 72 h / Ambient temperature
2: 80 percent / n-Bu4NBr, 50percent aq. NaOH / CH2Cl2 / 24 h / Ambient temperature
3: 87 percent / NH2OH*HCl, pyridine / ethanol / 2 h / Heating
4: NaH / dimethylformamide / 2 h / 20 °C
5: ethanol / 7 h / Heating
With
pyridine; hydrogenchloride; sodium hydroxide; hydroxylamine hydrochloride; tetrabutylammomium bromide; sodium hydride;
In
ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00122a008
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116823-21-3
(4bS,13aR)-13a-Methoxy-5,6,7,8,9,10,11,12,13,13a-decahydro-4bH-cycloundeca[a]inden-14-one
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118017-85-9
(4bR,13aS)-13a-Methoxy-5,6,7,8,9,10,11,12,13,13a-decahydro-4bH-cycloundeca[a]inden-14-one O-{3-[2-(3,5-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl}-oxime
- Guidance literature:
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Multi-step reaction with 3 steps
1: 87 percent / NH2OH*HCl, pyridine / ethanol / 2 h / Heating
2: NaH / dimethylformamide / 2 h / 20 °C
3: ethanol / 7 h / Heating
With
pyridine; hydroxylamine hydrochloride; sodium hydride;
In
ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00122a008
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116908-29-3
(4bS,13aR)-13a-Hydroxy-5,6,7,8,9,10,11,12,13,13a-decahydro-4bH-cycloundeca[a]inden-14-one
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118017-85-9
(4bR,13aS)-13a-Methoxy-5,6,7,8,9,10,11,12,13,13a-decahydro-4bH-cycloundeca[a]inden-14-one O-{3-[2-(3,5-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl}-oxime
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 80 percent / n-Bu4NBr, 50percent aq. NaOH / CH2Cl2 / 24 h / Ambient temperature
2: 87 percent / NH2OH*HCl, pyridine / ethanol / 2 h / Heating
3: NaH / dimethylformamide / 2 h / 20 °C
4: ethanol / 7 h / Heating
With
pyridine; sodium hydroxide; hydroxylamine hydrochloride; tetrabutylammomium bromide; sodium hydride;
In
ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00122a008