3,5-DIMETHOXYPHENETHYLAMINE

Base Information

• Chemical Name: 3,5-DIMETHOXYPHENETHYLAMINE
• CAS No.: 3213-28-3
• Molecular Formula: C10H15NO2
• Molecular Weight: 181.235
• Hs Code.: 2922299090
• Mol file: 3213-28-3.mol

Synonyms:Phenethylamine,3,5-dimethoxy- (6CI,7CI,8CI);2-(3,5-Dimethoxyphenyl)ethanamine;2-(3,5-Dimethoxyphenyl)ethylamine;3,5-Dimethoxy-b-phenethylamine;3,5-Dimethoxyphenethylamine;Benzeneethanamine, 3,5-dimethoxy-;

Chemical Property of 3,5-DIMETHOXYPHENETHYLAMINE

Chemical Property:

• Appearance/Colour: UN 2735 8/PG 2
• Vapor Pressure: 0.00136mmHg at 25°C
• Refractive Index: n20/D 1.5100(lit.)
• Boiling Point: 297.3 °C at 760 mmHg
• PKA: 9.79±0.10(Predicted)
• Flash Point: 145.5 °C
• PSA: 44.48000
• Density: 1.041 g/cm³
• LogP: 1.90530

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,5-Dimethoxyphenethylamine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-DIMETHOXYPHENETHYLAMINE

There total 6 articles about 3,5-DIMETHOXYPHENETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3,5-dimethoxyphenylacetonitrile (13388-75-5) → 3,5-dimethoxyphenethylamine (3213-28-3)

Guidance literature:

With ammonia; hydrogen; In toluene; at 120 ℃; for 16h; under 22502.3 Torr; Autoclave;

DOI:10.1039/c8sc02807a

Reference yield: 58.0%

trans-1-(3,5-Dimethoxyphenyl)-2-nitroethylene (86255-43-8) → 3,5-dimethoxyphenethylamine (3213-28-3)

Guidance literature:

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; for 6.5h; Inert atmosphere; Reflux;

DOI:10.1021/acs.joc.8b02888

Reference yield: 54.0%

1,3-dimethoxy-5-(2-nitroethenyl)benzene (86255-43-8,56723-84-3) → 3,5-dimethoxyphenethylamine (3213-28-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 50 ℃; for 144h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.6b00009

upstream raw materials:

3,5-dimethoxyphenylacetonitrile

1,4-Dihydro-3,5-dimethoxyphenylacetamid

1,3-dimethoxy-5-(2-nitroethenyl)benzene

1-bromo-3,5-dimethoxybenzene

Downstream raw materials:

3,5-dihydroxyphenylethylamine

2-isopropyl-1-[4-{3-[N-(3,5-dimethoxy-β-phenethyl)amino]propyloxy}benzenesulphonyl]indolizine

(4aS,9aR)-7-Fluoro-9a-methoxy-1,2,3,4,4a,9a-hexahydro-fluoren-9-one O-{3-[2-(3,5-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl}-oxime

(4bR,13aS)-13a-Methoxy-5,6,7,8,9,10,11,12,13,13a-decahydro-4bH-cycloundeca[a]inden-14-one O-{3-[2-(3,5-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl}-oxime

Refernces

• 1、 Zhao, Jianxiong,Méndez-Sánchez, Daniel,Ward, John M.,Hailes, Helen C.. "Biomimetic Phosphate-Catalyzed Pictet-Spengler Reaction for the Synthesis of 1,1′-Disubstituted and Spiro-Tetrahydroisoquinoline Alkaloids". . p. 7702 - 7710. Retrieved 2019/06/17.
• 2、 Murugesan, Kathiravan,Senthamarai, Thirusangumurugan,Sohail, Manzar,Alshammari, Ahmad S.,Pohl, Marga-Martina,Beller, Matthias,Jagadeesh, Rajenahally V.. "Cobalt-based nanoparticles prepared from MOF-carbon templates as efficient hydrogenation catalysts". . p. 8553 - 8560. Retrieved 2018/11/30.