1(6H)-Pyridazinepropanoic acid, 6-imino-5-methyl-3-phenyl-, monohydrobromide

Base Information

• Chemical Name: 1(6H)-Pyridazinepropanoic acid, 6-imino-5-methyl-3-phenyl-, monohydrobromide
• CAS No.: 105537-57-3
• Molecular Formula: C14H15N3O2.BrH
• Molecular Weight: 338.204
• Mol file: 105537-57-3.mol

Synonyms:

Chemical Property of 1(6H)-Pyridazinepropanoic acid, 6-imino-5-methyl-3-phenyl-, monohydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1(6H)-Pyridazinepropanoic acid, 6-imino-5-methyl-3-phenyl-, monohydrobromide

There total 5 articles about 1(6H)-Pyridazinepropanoic acid, 6-imino-5-methyl-3-phenyl-, monohydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-Amino-1-(2-ethoxycarbonyl-ethyl)-5-methyl-3-phenyl-pyridazin-1-ium; bromide (105538-10-1) → 6-Amino-1-(2-carboxy-ethyl)-5-methyl-3-phenyl-pyridazin-1-ium; bromide (105537-57-3)

Guidance literature:

With hydrogen bromide; In acetic acid; at 100 ℃; for 10h;

DOI:10.1021/jm00385a003

Reference yield:

3-chloro-4-methyl-6-phenylpyridazine (28657-39-8) → 6-Amino-1-(2-carboxy-ethyl)-5-methyl-3-phenyl-pyridazin-1-ium; bromide (105537-57-3)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrazine hydrate / butan-1-ol / 6 h / 100 °C

2: H₂ / Raney Ni / methanol / 20 °C / 760 Torr

3: dimethylformamide / 8 h / 80 °C

4: 48percentHBr / acetic acid / 10 h / 100 °C

With hydrogen bromide; hydrogen; hydrazine hydrate; nickel; In methanol; acetic acid; N,N-dimethyl-formamide; butan-1-ol;

DOI:10.1021/jm00385a003

Reference yield:

4-methyl-6-phenylpyridazin-3(2H)-one (13300-09-9) → 6-Amino-1-(2-carboxy-ethyl)-5-methyl-3-phenyl-pyridazin-1-ium; bromide (105537-57-3)

Guidance literature:

Multi-step reaction with 5 steps

1: phosphorus oxychloride / 4 h / 85 - 95 °C

2: hydrazine hydrate / butan-1-ol / 6 h / 100 °C

3: H₂ / Raney Ni / methanol / 20 °C / 760 Torr

4: dimethylformamide / 8 h / 80 °C

5: 48percentHBr / acetic acid / 10 h / 100 °C

With hydrogen bromide; hydrogen; hydrazine hydrate; trichlorophosphate; nickel; In methanol; acetic acid; N,N-dimethyl-formamide; butan-1-ol;

DOI:10.1021/jm00385a003

upstream raw materials:

6-Amino-1-(2-ethoxycarbonyl-ethyl)-5-methyl-3-phenyl-pyridazin-1-ium; bromide

3-chloro-4-methyl-6-phenylpyridazine

4-methyl-6-phenylpyridazin-3(2H)-one

3-amino-4-methyl-6-phenyl-pyridazine

Refernces