Technology Process of N-[(R)-1-(2'-Benzyloxymethyl-6,4',6'-trimethoxy-biphenyl-3-yl)-2-hydroxy-ethyl]-acetamide
There total 15 articles about N-[(R)-1-(2'-Benzyloxymethyl-6,4',6'-trimethoxy-biphenyl-3-yl)-2-hydroxy-ethyl]-acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 12 steps
1: 96 percent / NBS / CHCl3 / 45 °C
2: 90 percent / PDC / CHCl3
3: 85 percent / NaClO2 / dimethylsulfoxide / 12 h / Ambient temperature
4: SOCl2 / Heating
5: Et3N, DMAP / CHCl3 / 0 °C
6: 25 percent / NaOAc / Pd(PPh3)2Cl2 / N,N-dimethyl-acetamide / 130 °C
7: 68 percent / LiAlH4 / tetrahydrofuran / Ambient temperature
8: 90 percent / K2CO3 / acetone / 3 h / Ambient temperature
9: 80 percent / NaH / tetrahydrofuran / 20 h / Ambient temperature
10: p-TsOH / methanol / 6 h / 60 °C
11: Et3N, DMAP / CHCl3 / Ambient temperature
12: K2CO3 / methanol / 0.17 h
With
dmap; sodium chlorite; N-Bromosuccinimide; lithium aluminium tetrahydride; dipyridinium dichromate; thionyl chloride; sodium acetate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; methanol; chloroform; N,N-dimethyl acetamide; dimethyl sulfoxide; acetone;
DOI:10.1016/0040-4039(92)88096-N
- Guidance literature:
-
Multi-step reaction with 8 steps
1: Et3N, DMAP / CHCl3 / 0 °C
2: 25 percent / NaOAc / Pd(PPh3)2Cl2 / N,N-dimethyl-acetamide / 130 °C
3: 68 percent / LiAlH4 / tetrahydrofuran / Ambient temperature
4: 90 percent / K2CO3 / acetone / 3 h / Ambient temperature
5: 80 percent / NaH / tetrahydrofuran / 20 h / Ambient temperature
6: p-TsOH / methanol / 6 h / 60 °C
7: Et3N, DMAP / CHCl3 / Ambient temperature
8: K2CO3 / methanol / 0.17 h
With
dmap; lithium aluminium tetrahydride; sodium acetate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; methanol; chloroform; N,N-dimethyl acetamide; acetone;
DOI:10.1016/0040-4039(92)88096-N
- Guidance literature:
-
Multi-step reaction with 9 steps
1: SOCl2 / Heating
2: Et3N, DMAP / CHCl3 / 0 °C
3: 25 percent / NaOAc / Pd(PPh3)2Cl2 / N,N-dimethyl-acetamide / 130 °C
4: 68 percent / LiAlH4 / tetrahydrofuran / Ambient temperature
5: 90 percent / K2CO3 / acetone / 3 h / Ambient temperature
6: 80 percent / NaH / tetrahydrofuran / 20 h / Ambient temperature
7: p-TsOH / methanol / 6 h / 60 °C
8: Et3N, DMAP / CHCl3 / Ambient temperature
9: K2CO3 / methanol / 0.17 h
With
dmap; lithium aluminium tetrahydride; thionyl chloride; sodium acetate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; methanol; chloroform; N,N-dimethyl acetamide; acetone;
DOI:10.1016/0040-4039(92)88096-N