Technology Process of 4-(3,5-dimethylphenyl)-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole
There total 5 articles about 4-(3,5-dimethylphenyl)-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-amino-2-(3,5-dimethylphenyl)ethanol; 2-(diphenylphosphanyl)benzonitrile;
With
zinc(II) chloride;
In
chlorobenzene;
Reflux;
Inert atmosphere;
With
[2,2]bipyridinyl;
In
chloroform;
at 20 ℃;
Inert atmosphere;
DOI:10.1021/ja111700e
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium azide; acetic acid / water; acetone / 50 °C / Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 20 °C / Inert atmosphere
3.1: zinc(II) chloride / chlorobenzene / Reflux; Inert atmosphere
3.2: 20 °C / Inert atmosphere
With
sodium azide; palladium 10% on activated carbon; hydrogen; acetic acid; zinc(II) chloride;
In
ethanol; water; chlorobenzene; acetone;
DOI:10.1021/ja111700e
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: water; potassium hydroxide / acetonitrile / 4 h / 60 °C / Inert atmosphere
2.1: sodium azide; acetic acid / water; acetone / 50 °C / Inert atmosphere
3.1: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 20 °C / Inert atmosphere
4.1: zinc(II) chloride / chlorobenzene / Reflux; Inert atmosphere
4.2: 20 °C / Inert atmosphere
With
sodium azide; palladium 10% on activated carbon; water; hydrogen; acetic acid; potassium hydroxide; zinc(II) chloride;
In
ethanol; water; chlorobenzene; acetone; acetonitrile;
DOI:10.1021/ja111700e
