N-(2,6-diisopropylphenyl)-3-phenylacrylamide

Base Information

• Chemical Name: N-(2,6-diisopropylphenyl)-3-phenylacrylamide
• CAS No.: 463973-62-8
• Molecular Formula: C₂₁H₂₅NO
• Molecular Weight: 307.436
• Mol file: 463973-62-8.mol

Synonyms:

Chemical Property of N-(2,6-diisopropylphenyl)-3-phenylacrylamide

Chemical Property:

Purity/Quality:

N-(2,6-DIISOPROPYLPHENYL)-3-PHENYLACRYLAMIDE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2,6-diisopropylphenyl)-3-phenylacrylamide

There total 2 articles about N-(2,6-diisopropylphenyl)-3-phenylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

N-(2,6-diisopropylphenyl) acetamide (16637-13-1) + benzyl alcohol (100-51-6,185532-71-2) → N-(2,6-diisopropylphenyl)cinnamamide (463973-62-8)

Guidance literature:

With (4-Me)Triaz(NHPⁱPr₂)₂Mn(CO)₂Br; caesium carbonate; In tert-Amyl alcohol; at 135 ℃; for 24h; Inert atmosphere; Schlenk technique; Glovebox;

DOI:10.1021/acs.joc.1c00685

Reference yield:

2,6-diisopropylbenzenamine (24544-04-5) → N-(2,6-diisopropylphenyl)cinnamamide (463973-62-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.17 h / Cooling with ice

1.2: 2.25 h

2.1: (4-Me)Triaz(NHPⁱPr₂)₂Mn(CO)₂Br; caesium carbonate / tert-Amyl alcohol / 24 h / 135 °C / Inert atmosphere; Schlenk technique; Glovebox

With (4-Me)Triaz(NHPⁱPr₂)₂Mn(CO)₂Br; caesium carbonate; triethylamine; In tert-Amyl alcohol; dichloromethane;

DOI:10.1021/acs.joc.1c00685

upstream raw materials:

N-(2,6-diisopropylphenyl) acetamide

benzyl alcohol

2,6-diisopropylbenzenamine

Refernces