2-(N,N-dimethylamino)-6-methylphenyl trifluoromethanesulfonate

Base Information

• Chemical Name: 2-(N,N-dimethylamino)-6-methylphenyl trifluoromethanesulfonate
• CAS No.: 1616786-35-6
• Molecular Formula: C₁₀H₁₂F₃NO₃S
• Molecular Weight: 283.271
• Mol file: 1616786-35-6.mol

Synonyms:

Chemical Property of 2-(N,N-dimethylamino)-6-methylphenyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(N,N-dimethylamino)-6-methylphenyl trifluoromethanesulfonate

There total 2 articles about 2-(N,N-dimethylamino)-6-methylphenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + m-methyl-N,N-dimethylaniline-N-oxide (825-80-9) → 2-(N,N-dimethylamino)-4-methylphenyl trifluoromethanesulfonate (1616786-34-5) + 2-(N,N-dimethylamino)-6-methylphenyl trifluoromethanesulfonate (1616786-35-6)

Guidance literature:

trifluoromethylsulfonic anhydride; m-methyl-N,N-dimethylaniline-N-oxide; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - 0 ℃; for 1h; Overall yield = 79 %; Inert atmosphere;

DOI:10.1021/ol501813s

Reference yield:

N,N-dimethyl-m-toluidine (121-72-2) → 2-(N,N-dimethylamino)-4-methylphenyl trifluoromethanesulfonate (1616786-34-5) + 2-(N,N-dimethylamino)-6-methylphenyl trifluoromethanesulfonate (1616786-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 23 °C / Inert atmosphere

2.1: dichloromethane / 1 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 - 0 °C / Inert atmosphere

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1021/ol501813s

upstream raw materials:

trifluoromethylsulfonic anhydride

m-methyl-N,N-dimethylaniline-N-oxide

N,N-dimethyl-m-toluidine

Refernces