(Sp)-methyl N-<2-hydroxymethylphenoxy(octyl)phosphonyl> L-prolinate

Base Information

• Chemical Name: (Sp)-methyl N-<2-hydroxymethylphenoxy(octyl)phosphonyl> L-prolinate
• CAS No.: 172370-54-6
• Molecular Formula: C₂₁H₃₄NO₅P
• Molecular Weight: 411.478
• Mol file: 172370-54-6.mol

Synonyms:

Chemical Property of (Sp)-methyl N-<2-hydroxymethylphenoxy(octyl)phosphonyl> L-prolinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Sp)-methyl N-<2-hydroxymethylphenoxy(octyl)phosphonyl> L-prolinate

There total 2 articles about (Sp)-methyl N-<2-hydroxymethylphenoxy(octyl)phosphonyl> L-prolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

salicylic alcohol (90-01-7) + methyl N- L-prolinate → (Sp)-methyl N-<2-hydroxymethylphenoxy(octyl)phosphonyl> L-prolinate (172370-54-6) + (Rp)-methyl N-<2-hydroxymethylphenoxy(octyl)phosphonyl> L-prolinate (172370-53-5)

Guidance literature:

With triethylamine; In dichloromethane; for 2h; Ambient temperature;

Reference yield:

Octyl-P(O)Cl2 (3095-94-1) → (Sp)-methyl N-<2-hydroxymethylphenoxy(octyl)phosphonyl> L-prolinate (172370-54-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 1 h / -60 - 20 °C

2: 29 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

With triethylamine; In dichloromethane;

Reference yield: 91.0%

(Sp)-methyl N-<2-hydroxymethylphenoxy(octyl)phosphonyl> L-prolinate (172370-54-6) → (Sp)-2-octyl-4H-1,3,2-benzodioxaphosphorin 2-oxides (142840-32-2)

Guidance literature:

With hydrogenchloride; In diethyl ether; for 0.5h; Ambient temperature;

upstream raw materials:

salicylic alcohol

Octyl-P(O)Cl₂

Downstream raw materials:

(Sp)-2-octyl-4H-1,3,2-benzodioxaphosphorin 2-oxides

Refernces