Technology Process of 5-Isobutoxycarbonyloxy-5-oxo-pentanoic acid (3S,8R,9S,10R,13R,14S,17R)-14-hydroxy-10,13-dimethyl-17-(6-oxo-6H-pyran-3-yl)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester
There total 3 articles about 5-Isobutoxycarbonyloxy-5-oxo-pentanoic acid (3S,8R,9S,10R,13R,14S,17R)-14-hydroxy-10,13-dimethyl-17-(6-oxo-6H-pyran-3-yl)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester which
guide to synthetic route it.
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synthetic route:
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1060725-90-7
5-Isobutoxycarbonyloxy-5-oxo-pentanoic acid (3S,8R,9S,10R,13R,14S,17R)-14-hydroxy-10,13-dimethyl-17-(6-oxo-6H-pyran-3-yl)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester
- Guidance literature:
-
With
triethylamine;
In
tetrahydrofuran;
at -15 ℃;
for 0.5h;
DOI:10.1248/cpb.42.2256
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-
1060725-90-7
5-Isobutoxycarbonyloxy-5-oxo-pentanoic acid (3S,8R,9S,10R,13R,14S,17R)-14-hydroxy-10,13-dimethyl-17-(6-oxo-6H-pyran-3-yl)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester
- Guidance literature:
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Multi-step reaction with 2 steps
1: 98 percent / DMAP / CH2Cl2 / 2 h / Ambient temperature
2: Et3N / tetrahydrofuran / 0.5 h / -15 °C
With
dmap; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.42.2256
-
-
1060725-90-7
5-Isobutoxycarbonyloxy-5-oxo-pentanoic acid (3S,8R,9S,10R,13R,14S,17R)-14-hydroxy-10,13-dimethyl-17-(6-oxo-6H-pyran-3-yl)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester
- Guidance literature:
-
Multi-step reaction with 3 steps
1: naringinase, acetate buffer / ethanol / 40 °C / var. temp., solvents, and pH
2: 98 percent / DMAP / CH2Cl2 / 2 h / Ambient temperature
3: Et3N / tetrahydrofuran / 0.5 h / -15 °C
With
dmap; naringinase; acetate buffer; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1248/cpb.42.2256