dihydroxyprehnitene

Base Information

• Chemical Name: dihydroxyprehnitene
• CAS No.: 3938-11-2
• Molecular Formula: C₁₀H₁₄O₂
• Molecular Weight: 166.22
• Mol file: 3938-11-2.mol

Synonyms:

Chemical Property of dihydroxyprehnitene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dihydroxyprehnitene

There total 4 articles about dihydroxyprehnitene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-diamino-3,4,5,6-tetramethylbenzene (67130-14-7) → dihydroxyprehnitene (3938-11-2)

Guidance literature:

With hydrogenchloride; chlorine; acetic acid; Kochen des Reaktionsprodukts mit konz. wss. HCl und SnCl₂;

DOI:10.1021/ja01317a064

Reference yield:

1,2,3,4-Tetramethylbenzene (488-23-3) → dihydroxyprehnitene (3938-11-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / Br₂ / CH₂Cl₂ / 2 h

2: 6.02 g / sodium; CuI / dimethylformamide / 14 h / 120 °C

3: 1.52 g / conc. HBr; tetra-n-butylammonium bromide / 3 h / Heating

With copper(l) iodide; tetrabutylammomium bromide; hydrogen bromide; bromine; sodium; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2004.07.017

Reference yield:

1,2-dibromo-3,4,5,6-tetramethylbenzene (36321-73-0) → dihydroxyprehnitene (3938-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 6.02 g / sodium; CuI / dimethylformamide / 14 h / 120 °C

2: 1.52 g / conc. HBr; tetra-n-butylammonium bromide / 3 h / Heating

With copper(l) iodide; tetrabutylammomium bromide; hydrogen bromide; sodium; In N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2004.07.017

upstream raw materials:

1,2-diamino-3,4,5,6-tetramethylbenzene

dimethoxyprehnitene

1,2,3,4-Tetramethylbenzene

1,2-dibromo-3,4,5,6-tetramethylbenzene

Downstream raw materials:

3,4,5,6-Tetrabromo-1,2-dimethoxybenzene

dimethoxyprehnitene

tetramethyl-o-quinone

Refernces