2,6-DIPIPERIDIN-1-YLPYRIDINE

Base Information

• Chemical Name: 2,6-DIPIPERIDIN-1-YLPYRIDINE
• CAS No.: 3980-49-2
• Molecular Formula: C₁₅H₂₃N₃
• Molecular Weight: 245.368
• Mol file: 3980-49-2.mol

Synonyms:

Chemical Property of 2,6-DIPIPERIDIN-1-YLPYRIDINE

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-DIPIPERIDIN-1-YLPYRIDINE

There total 7 articles about 2,6-DIPIPERIDIN-1-YLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

piperidine (110-89-4) + 2,6-Dibromopyridine (626-05-1) → 2-bromo-6-(piperidin-1-yl)pyridine (24255-97-8) + 2,6-di(piperidine-1-yl)pyridine (3980-49-2)

Guidance literature:

With potassium fluoride on basic alumina; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; at 135 ℃; for 3h;

DOI:10.1055/s-2005-865241

Reference yield: 89.0%

piperidine (110-89-4) + 2,6-dichloropyridine (2402-78-0) → 2,6-di(piperidine-1-yl)pyridine (3980-49-2) + 2-chloro-6-(1-piperidyl)pyridine (19946-28-2)

Guidance literature:

at 60 ℃; for 96h; under 6000480 Torr;

DOI:10.3987/COM-87-4371

Reference yield: 78.0%

piperidine (110-89-4) + 2,6-Dibromopyridine (626-05-1) → 2,6-di(piperidine-1-yl)pyridine (3980-49-2)

Guidance literature:

With copper(l) iodide; In water; at 190 ℃; for 4h; Sealed tube; Microwave irradiation;

DOI:10.1016/j.tet.2015.08.042

upstream raw materials:

piperidine

pyridine

2-bromo-6-(piperidin-1-yl)pyridine

2,6-dichloropyridine

Refernces

• 1、 Prabhu, Rupesh Narayana,Ramesh, Rengan. "Synthesis and structural characterization of palladium(II) thiosemicarbazone complex: Application to the Buchwald-Hartwig amination reaction". . p. 1120 - 1124. Retrieved 2013/03/13.
• 2、 Basu, Basudeb,Das, Pralay,Nanda, Ashish K.,Das, Sajal,Sarkar, Sajal. "Palladium-catalyzed selective amination of haloaromatics on KF-alumina surface". . p. 1275 - 1278. Retrieved 2007/10/03.