6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR

Base Information

• Chemical Name: 6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR
• CAS No.: 52853-40-4
• Molecular Formula: C7H8Br2N6
• Molecular Weight: 335.989
• Hs Code.: 2933990090
• Mol file: 52853-40-4.mol

Synonyms:2,4-Pteridinediamine,6-(bromomethyl)-, monohydrobromide (9CI);2,4-Diamino-6-(bromomethyl)pteridinehydrobromide;6-(Bromomethyl)-2,4-diaminopteridine hydrobromide;6-(Bromomethyl)-2,4-pteridinediamine hydrobromide;

Chemical Property of 6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR

Chemical Property:

• Appearance/Colour: light brown solid
• Vapor Pressure: 1.6E-11mmHg at 25°C
• Melting Point: >195 °C (dec.)
• Boiling Point: 524.7 °C at 760 mmHg
• Flash Point: 271.1 °C
• PSA: 103.60000
• LogP: 2.59960
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

6-(Bromomethyl)-2,4-pteridinediamineHydrobromide(TechnicalGrade) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide can be used as organic synthesis intermediate and pharmaceutical intermediate.

Technology Process of 6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR

There total 6 articles about 6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

β-bromopyruvaldoxime + 2,4,5,6-tetraminopyrimidine dihydrobromide → 6-bromomethyl-2,4-diaminopteridine hydrobromide (52853-40-4)

Guidance literature:

β-bromopyruvaldoxime; 2,4,5,6-tetraminopyrimidine dihydrobromide; In methanol; for 2h; Heating / reflux;

With ammonia; at 20 ℃; for 2h; Product distribution / selectivity;

Reference yield: 88.0%

3-bromoacetonaldoxime (37150-52-0) + 2,4,5,6-tetraminopyrimidine dihydrobromide → 6-bromomethyl-2,4-diaminopteridine hydrobromide (52853-40-4)

Guidance literature:

In methanol; for 2h; Heating / reflux;

Reference yield: 49.0%

2,4-diamino-6-hydroxymethylpteridine hydrobromide (76145-91-0) → 6-bromomethyl-2,4-diaminopteridine hydrobromide (52853-40-4)

Guidance literature:

With dibromotriphenylphosphorane; In dimethylacetamide (DMAC); at 20 - 25 ℃; for 2h; Product distribution / selectivity;

upstream raw materials:

2,4-diamino-6-(hydroxymethyl)pteridine

2,4-diamino-6-hydroxymethylpteridine hydrobromide

2,4-diamino-6-(hydroxymethyl)pteridine hydrochloride

diethyl ether

Downstream raw materials:

(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-3-methyl-benzoylamino}-pentanedioic acid diethyl ester

(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-3-methyl-benzoylamino}-hexanedioic acid dimethyl ester

(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-3-methyl-benzoylamino}-hexanedioic acid dimethyl ester

(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-3-methyl-benzoylamino}-pentanedioic acid diethyl ester

Refernces

• 1、 -. "Aminopterin dosage forms and methods for inflammatory disorders". Page/Page column 12. . Retrieved 2008/06/13.
• 2、 Graffner-Nordberg, Malin,Fyfe, Meredith,Brattsand, Ralph,Mellg?rd, Bj?rn,Hallberg, Anders. "Design and synthesis of dihydrofolate reductase inhibitors encompassing a bridging ester group. Evaluation in a mouse colitis model". . p. 3455 - 3462. Retrieved 2007/10/03.