6-Methoxy-2,3-dimethylquinoxalin-5-amine

Base Information

• Chemical Name: 6-Methoxy-2,3-dimethylquinoxalin-5-amine
• CAS No.: 32387-83-0
• Molecular Formula: C11H13N3O
• Molecular Weight: 203.244
• European Community (EC) Number: 251-019-8
• DSSTox Substance ID: DTXSID1067679
• Nikkaji Number: J29.051C
• Wikidata: Q81994315
• Mol file: 32387-83-0.mol

Synonyms:6-Methoxy-2,3-dimethylquinoxalin-5-amine;32387-83-0;5-Quinoxalinamine, 6-methoxy-2,3-dimethyl-;EINECS 251-019-8;2,3-Dimethyl-5-amino-6-methoxyquinoxaline;5-QUINOXALINAMINE,6-METHOXY-2,3-DIMETHYL-;DTXSID1067679;SCHEMBL11208368;AMY7726;MFCD09834451;AKOS030228491;DS-19360;5-Amino-6-methoxy-2,3-dimethylquinoxaline;CS-0160568;A11531;A918175

Chemical Property of 6-Methoxy-2,3-dimethylquinoxalin-5-amine

Chemical Property:

• Vapor Pressure: 3.13E-05mmHg at 25°C
• Refractive Index: 1.64
• Boiling Point: 355.4 °C at 760 mmHg
• PKA: 2.65±0.48(Predicted)
• Flash Point: 168.7 °C
• PSA: 61.03000
• Density: 1.203 g/cm³
• LogP: 2.41860
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 203.105862047
• Heavy Atom Count: 15
• Complexity: 224

Purity/Quality:

99%, ^*data from raw suppliers

6-Methoxy-2,3-dimethylquinoxalin-5-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N=C2C(=N1)C=CC(=C2N)OC)C

Technology Process of 6-Methoxy-2,3-dimethylquinoxalin-5-amine

There total 9 articles about 6-Methoxy-2,3-dimethylquinoxalin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

→ tert-butylhypochlorite (507-40-4)

Guidance literature:

Reference yield: 75.0%

tert-butyl alcohol (75-65-0) → tert-butylhypochlorite (507-40-4)

Guidance literature:

With sodium hypochlorite; acetic acid; In water; at 0 ℃; for 0.166667h; Darkness;

DOI:10.1016/j.tetasy.2015.11.003

Reference yield: 75.0%

tert-butyl alcohol (75-65-0) → tert-butyl hypochloride (507-40-4)

Guidance literature:

With sodium hypochlorite; In acetic acid;

DOI:10.1021/jo00165a008

upstream raw materials:

dimethyl-2,3 methoxy-6 nitro-5 quinoxaline

tert-butyl alcohol

hypochloric acid

sodium hypochlorite

Refernces

• 1、 Pastoriza, Cristina,Antelo, Juan Manuel,Crugeiras, Juan. "Oxidation of bromide by tert-butyl hypochlorite". . p. 629 - 637. Retrieved 2013.
• 2、 Bentzinger, Guillaume,De Souza, Wesley,Mullié, Catherine,Agnamey, Patrice,Dassonville-Klimpt, Alexandra,Sonnet, Pascal. "Asymmetric synthesis of new antimalarial aminoquinolines through Sharpless aminohydroxylation". . p. 1 - 11. Retrieved 2016.
• 3、 Kassin, Victor-Emmanuel H.,Morodo, Romain,Toupy, Thomas,Jacquemin, Isaline,Van Hecke, Kristof,Robiette, Rapha?l,Monbaliu, Jean-Christophe M.. "A modular, low footprint and scalable flow platform for the expedient α-aminohydroxylation of enolizable ketones". supporting information. p. 2336 - 2351. Retrieved 2021/04/07.
• 4、 Han, Chunyu,Liu, Yaowen,Tian, Xianhai,Rominger, Frank,Hashmi, A. Stephen K.. "Dual Gold/Silver Catalysis: Indolizines from 2-Substituted Pyridine Derivatives via a Tandem C(sp3)–H Alkynylation/Iminoauration". supporting information. p. 9480 - 9484. Retrieved 2021/12/17.