dNBS-Gly-Val-(Ac3-Tn-α-Thr)-Ser-Ala-OH

Base Information

• Chemical Name: dNBS-Gly-Val-(Ac3-Tn-α-Thr)-Ser-Ala-OH
• CAS No.: 1333013-95-8
• Molecular Formula: C₃₇H₅₂N₈O₂₂S
• Molecular Weight: 992.926
• Mol file: 1333013-95-8.mol

Synonyms:

Chemical Property of dNBS-Gly-Val-(Ac3-Tn-α-Thr)-Ser-Ala-OH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dNBS-Gly-Val-(Ac3-Tn-α-Thr)-Ser-Ala-OH

There total 1 articles about dNBS-Gly-Val-(Ac3-Tn-α-Thr)-Ser-Ala-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

Fmoc-Ala-O-Wang resin + 2,4-dinitrobenzenesulfonyl chloride (1656-44-6) + N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + Fmoc-Val-OH (68858-20-8) + Fmoc-Ser(tBu)-OH (71989-33-8) + N-(9H-fluoren-9-yl)methoxycarbonyl-O-(3,4,6-tri-O-acetyl-2-acetamido-2-deoxy-α-D-galactopyranosyl)-L-threonine (116783-35-8) → dNBS-Gly-Val-(Ac3-Tn-α-Thr)-Ser-Ala-OH (1333013-95-8)

Guidance literature:

Fmoc-Ala-O-Wang resin; With piperidine; In N,N-dimethyl-formamide; for 0.416667h; Inert atmosphere; solid phase reaction;

Fmoc-Ser(tBu)-OH; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; Inert atmosphere; solid phase reaction;

2,4-dinitrobenzenesulfonyl chloride; N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Val-OH; N-(9H-fluoren-9-yl)methoxycarbonyl-O-(3,4,6-tri-O-acetyl-2-acetamido-2-deoxy-α-D-galactopyranosyl)-L-threonine; Further stages;

DOI:10.1021/ol202163e

upstream raw materials:

2,4-dinitrobenzenesulfonyl chloride

N-(fluoren-9-ylmethoxycarbonyl)glycine

Fmoc-Val-OH

Fmoc-Ser(tBu)-OH

Refernces