4,7-Dihydro Megestrol Acetate

Base Information

• Chemical Name: 4,7-Dihydro Megestrol Acetate
• CAS No.: 14994-27-5
• Molecular Formula: C₂₄H₃₄O₄
• Molecular Weight: 386.532
• Mol file: 14994-27-5.mol

Synonyms:

Chemical Property of 4,7-Dihydro Megestrol Acetate

Chemical Property:

Purity/Quality:

95% min ^*data from raw suppliers

4,7-DihydroMegestrolAcetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4,7-Dihydro Megestrol Acetate (Megestrol Acetate EP Impurity J) is an impurity of Megestrol Acetate (M208050) which is an orally active progestogen. It is formerly used in combinations as oral contraceptive.on

Technology Process of 4,7-Dihydro Megestrol Acetate

There total 3 articles about 4,7-Dihydro Megestrol Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

17α-Acetoxy-3-trichloracetoxy-6-methyl-Δ3,5-pregnadien-20-on (22223-98-9) → 17α-Acetoxy-6-methyl-Δ5-pregnen-3,20-dion (14994-27-5)

Guidance literature:

With triethylamine; In methanol;

DOI:10.1016/S0040-4020(01)82744-7

Reference yield:

Medroxyprogesterone acetate (71-58-9) → 17α-Acetoxy-6-methyl-Δ5-pregnen-3,20-dion (14994-27-5)

Guidance literature:

Multi-step reaction with 2 steps

2: Et₃N / methanol

With triethylamine; In methanol;

DOI:10.1016/S0040-4020(01)82744-7

Reference yield:

→ Acetic acid (10R,13S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester (14994-27-5)

Guidance literature:

entspr. ROH, Oxidation;

upstream raw materials:

17α-Acetoxy-3-trichloracetoxy-6-methyl-Δ^3,5-pregnadien-20-on

Medroxyprogesterone acetate

Downstream raw materials:

3-cycloethylenedioxy-6-methyl-17α-acetoxy-pregn-5-ene-20-one