Acetic acid, 2,2,2-trifluoro-, 1,2-diMethylpropyl ester

Base Information

• Chemical Name: Acetic acid, 2,2,2-trifluoro-, 1,2-diMethylpropyl ester
• CAS No.: 691-75-8
• Molecular Formula: C₇H₁₁F₃O₂
• Molecular Weight: 184.158
• Mol file: 691-75-8.mol

Synonyms:

Chemical Property of Acetic acid, 2,2,2-trifluoro-, 1,2-diMethylpropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid, 2,2,2-trifluoro-, 1,2-diMethylpropyl ester

There total 3 articles about Acetic acid, 2,2,2-trifluoro-, 1,2-diMethylpropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3-methyl-2-butanol (598-75-4) + trifluoroacetic anhydride (407-25-0) → 3-methyl-2-butyl trifluoroacetate (691-75-8)

Guidance literature:

With pyridine; at 0 ℃; for 120h;

DOI:10.1021/jo00080a025

Reference yield:

3-methylbutan-2-yl 4-methylbenzenesulfonate (26466-06-8) + potassium trifluoroacetate (2923-16-2) → 2-Methyl-2-butyl trifluoroacetate (461-73-4) + 3-methyl-2-butyl trifluoroacetate (691-75-8)

Guidance literature:

With trifluoroacetic anhydride; In trifluoroacetic acid; at 25 ℃; Rate constant; Mechanism; other temp.; also in TFA-d, and in a mixture TFA, TFA-18O and TFA-18O₂; kinetic isotope effect;

DOI:10.1021/jo00080a025

Reference yield:

3-Methyl-1-butene (563-45-1) + trifluoroacetic acid (76-05-1) → 2-Methyl-2-butyl trifluoroacetate (461-73-4) + 3-methyl-2-butyl trifluoroacetate (691-75-8)

Guidance literature:

at 26.5 ℃; Rate constant; Product distribution; Mechanism; various temp.; in the presence of MeCN or p-TsOH; also with TFA-d;

DOI:10.1021/jo00080a026

upstream raw materials:

3-methylbutan-2-yl 4-methylbenzenesulfonate

potassium trifluoroacetate

3-Methyl-1-butene

trifluoroacetic acid

Refernces

• 1、 Farcasiu, Dan,Marino, Gaye,Harris, J. Milton,Hovanes, Bruce A.,Hsu, Chang S.. "Secondary and Tertiary 2-Methylbutyl Cations. 1. Trifluoroacetolysis of 2-Methyl-2-butyl Tosylate". . p. 154 - 162. Retrieved 2007/10/02.