C₄₈H₅₄N₄O₁₂

Base Information

• Chemical Name: C₄₈H₅₄N₄O₁₂
• CAS No.: 1416793-43-5
• Molecular Formula: C₄₈H₅₄N₄O₁₂
• Molecular Weight: 878.976
• Mol file: 1416793-43-5.mol

Synonyms:

Chemical Property of C₄₈H₅₄N₄O₁₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₈H₅₄N₄O₁₂

There total 7 articles about C₄₈H₅₄N₄O₁₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-bis(2-aminophenoxy)ethane-N,N,N'N'-tetraacetic acid tetraethyl ester (122460-22-4) + C35H30N2O2P(1+)*Br(1-) (870789-47-2) → C48H54N4O12 (1416793-43-5)

Guidance literature:

C₃₅H₃₀N₂O₂P⁽¹⁺⁾*Br^(1-); With sodium hydride; In diethyl ether; at 20 ℃; for 1h; Inert atmosphere;

1,2-bis(2-aminophenoxy)ethane-N,N,N'N'-tetraacetic acid tetraethyl ester; In diethyl ether; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c2ob26888d

Reference yield:

1,2-bis(2-aminophenoxy)ethane-N,N,N'N'-tetraacetic acid tetraethyl ester (73630-07-6) → C48H54N4O12 (1416793-43-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / 0 - 70 °C

2.1: sodium hydride / diethyl ether / 1 h / 20 °C / Inert atmosphere

2.2: 4 h / 20 °C / Inert atmosphere

With pyridine; sodium hydride; In diethyl ether;

DOI:10.1039/c2ob26888d

Reference yield:

4-methyl-benzoyl chloride (874-60-2) → C48H54N4O12 (1416793-43-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: pyridine / chloroform / 3 h / Reflux

2.1: trichlorophosphate / 7 h / Reflux

3.1: N-Bromosuccinimide; dibenzoyl peroxide / benzene / 5 h / Reflux

4.1: benzene / 4 h / Reflux

5.1: sodium hydride / diethyl ether / 1 h / 20 °C / Inert atmosphere

5.2: 4 h / 20 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; sodium hydride; trichlorophosphate; dibenzoyl peroxide; In diethyl ether; chloroform; benzene;

DOI:10.1039/c2ob26888d

upstream raw materials:

1,2-bis(2-aminophenoxy)ethane-N,N,N'N'-tetraacetic acid tetraethyl ester

1,2-bis(2-aminophenoxy)ethane-N,N,N'N'-tetraacetic acid tetraethyl ester

C₃₅H₃₀N₂O₂P⁽¹⁺⁾*Br^(1-)

4-methyl-benzoyl chloride

Downstream raw materials:

C₄₀H₃₈N₄O₁₂

Refernces

• 1、 Liu, Qiao-Ling,Fan, Meng,Bian, Wei,Shuang, Shao-Min,Dong, Chuan. "Synthesis of a new ratiometric emission Ca2+ indicator for in vivo bioimaging". . p. 156 - 158. Retrieved 2013/07/19.