n-(4-Methoxyphenyl)naphthalen-2-amine

Base Information

• Chemical Name: n-(4-Methoxyphenyl)naphthalen-2-amine
• CAS No.: 6949-67-3
• Molecular Formula: C17H15 N O
• Molecular Weight: 249.312
• NSC Number: 22890
• DSSTox Substance ID: DTXSID80989440
• Nikkaji Number: J370.640K
• Wikidata: Q82978542
• ChEMBL ID: CHEMBL1721495
• Mol file: 6949-67-3.mol

Synonyms:MLS002638911;6949-67-3;n-(4-methoxyphenyl)naphthalen-2-amine;NSC22890;CHEMBL1721495;SCHEMBL14300546;DTXSID80989440;HMS3085O03;NSC-22890;AKOS022842492;SMR001548373

Chemical Property of n-(4-Methoxyphenyl)naphthalen-2-amine

Chemical Property:

• Vapor Pressure: 1.7E-07mmHg at 25°C
• Boiling Point: 427°C at 760 mmHg
• Flash Point: 172.8°C
• Density: 1.167g/cm³
• XLogP3: 5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 249.115364102
• Heavy Atom Count: 19
• Complexity: 272

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)NC2=CC3=CC=CC=C3C=C2

Technology Process of n-(4-Methoxyphenyl)naphthalen-2-amine

There total 14 articles about n-(4-Methoxyphenyl)naphthalen-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-Nitronaphthalene (86-57-7) + 4-methoxyphenylboronic acid (5720-07-0) → N-(p-anisyl)-2-naphthylamine (6949-67-3) + 1-amino-naphthalene (134-32-7)

Guidance literature:

With phenylsilane; copper diacetate; 1,4-di(diphenylphosphino)-butane; In toluene; acetonitrile; at 60 ℃; for 30h;

DOI:10.1021/acscatal.1c03113

Reference yield: 95.0%

naphthalen-2-yl tosylate (7385-85-5) + 4-methoxy-aniline (104-94-9) → N-(p-anisyl)-2-naphthylamine (6949-67-3)

Guidance literature:

With sodium t-butanolate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; chlorobis(triphenylphosphine)(1-naphthyl)nickel(II); In 1,4-dioxane; at 110 ℃; for 0.5h;

DOI:10.1021/jo7022558

Reference yield: 90.0%

2-Methoxynaphthalene (93-04-9) + 4-methoxy-aniline (104-94-9) → N-(p-anisyl)-2-naphthylamine (6949-67-3)

Guidance literature:

With trifluorormethanesulfonic acid; In neat (no solvent); at 120 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.6b02701

upstream raw materials:

4-methoxy-aniline

β-naphthol

N-(4-hydroxyphenyl)-2-naphthylamine

dimethyl sulfate

Downstream raw materials:

(4-Methoxy-phenyl)-(1,2,3,4-tetrahydro-naphthalen-2-yl)-amine

7-(4-methoxy-phenyl)-7H-dibenzo[c,g]carbazole

N-dichloromethyl-N-(4-methoxyphenyl)-N-(2-naphthyl)amine

N-(4-methoxyphenyl)-N-(2-naphthyl)formamide

Refernces

• 1、 Guan, Xinyu,Zhu, Haoran,Driver, Tom G.. "Cu-Catalyzed Cross-Coupling of Nitroarenes with Aryl Boronic Acids to Construct Diarylamines". . p. 12417 - 12422. Retrieved 2021/10/12.
• 2、 -. "COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTRONIC ELEMENT USING THE SAME, AND A ELECTRONIC DEVICE THEREOF". Paragraph 0123; 0127-0131. . Retrieved 2020/06/24.