(S)-1-azido-2-trimethylsilyloxy-3-tosyloxypropane

Base Information

• Chemical Name: (S)-1-azido-2-trimethylsilyloxy-3-tosyloxypropane
• CAS No.: 136404-80-3
• Molecular Formula: C₁₃H₂₁N₃O₄SSi
• Molecular Weight: 343.479
• Mol file: 136404-80-3.mol

Synonyms:

Chemical Property of (S)-1-azido-2-trimethylsilyloxy-3-tosyloxypropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-azido-2-trimethylsilyloxy-3-tosyloxypropane

There total 2 articles about (S)-1-azido-2-trimethylsilyloxy-3-tosyloxypropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trimethylsilylazide (4648-54-8) + (S)-Glycidyl tosylate (70987-78-9,6746-81-2) → (S)-1-azido-2-trimethylsilyloxy-3-tosyloxypropane (136404-80-3) + (R)-1-azido-2-trimethylsilyloxy-3-tosyloxypropane (136404-79-0)

Guidance literature:

With titanium(IV) isopropylate; In tetrahydrofuran; at 40 ℃; for 96h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0957-4166(00)82168-0

Reference yield:

trimethylsilylazide (4648-54-8) + (R)-glycidyl tosylate (113826-06-5,6746-81-2) → (S)-1-azido-2-trimethylsilyloxy-3-tosyloxypropane (136404-80-3) + (R)-1-azido-2-trimethylsilyloxy-3-tosyloxypropane (136404-79-0)

Guidance literature:

With titanium(IV) isopropylate; In tetrahydrofuran; at 40 ℃; for 96h; Product distribution; other reagent, time, and reactant; other glycidyl derivatives;

DOI:10.1016/S0957-4166(00)82168-0

Reference yield:

(S)-1-azido-2-trimethylsilyloxy-3-tosyloxypropane (136404-80-3) → (2S)-3-azido-2-hydroxypropyl p-toluenesulfonate (136459-47-7)

Guidance literature:

With hydrogenchloride; In methanol; for 4h; Ambient temperature;

DOI:10.1016/S0957-4166(00)82168-0

upstream raw materials:

trimethylsilylazide

(R)-glycidyl tosylate

(S)-Glycidyl tosylate

Downstream raw materials:

(2S)-3-azido-2-hydroxypropyl p-toluenesulfonate

Refernces