3,5-dihydroxyphenylacetamide

Base Information

• Chemical Name: 3,5-dihydroxyphenylacetamide
• CAS No.: 36034-03-4
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.164
• Mol file: 36034-03-4.mol

Synonyms:

Chemical Property of 3,5-dihydroxyphenylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-dihydroxyphenylacetamide

There total 7 articles about 3,5-dihydroxyphenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dimethoxybenzyl alcohol (705-76-0) → 3,5-dihydroxyphenylacetamide (36034-03-4)

Guidance literature:

Multi-step reaction with 5 steps

1: SOCl₂ / diethyl ether

2: ethanol

3: HI, AcOH

4: HCl

5: aq. NH₃

With hydrogenchloride; ammonium hydroxide; thionyl chloride; hydrogen iodide; acetic acid; In diethyl ether; ethanol;

DOI:10.1002/ardp.19723050211

Reference yield:

3,5-dimethoxybenzylchloride (6652-32-0) → 3,5-dihydroxyphenylacetamide (36034-03-4)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol

2: HI, AcOH

3: HCl

4: aq. NH₃

With hydrogenchloride; ammonium hydroxide; hydrogen iodide; acetic acid; In ethanol;

DOI:10.1002/ardp.19723050211

Reference yield:

methyl 3,5-dimethoxybenzoate (2150-37-0) → 3,5-dihydroxyphenylacetamide (36034-03-4)

Guidance literature:

Multi-step reaction with 6 steps

1: LiAlH₄ / diethyl ether

2: SOCl₂ / diethyl ether

3: ethanol

4: HI, AcOH

5: HCl

6: aq. NH₃

With hydrogenchloride; ammonium hydroxide; lithium aluminium tetrahydride; thionyl chloride; hydrogen iodide; acetic acid; In diethyl ether; ethanol;

DOI:10.1002/ardp.19723050211

upstream raw materials:

methyl 2-(3,5-dihydroxyphenyl)acetate

3,5-dimethoxybenzyl alcohol

3,5-dimethoxyphenylacetonitrile

3,5-dimethoxybenzylchloride

Refernces

• 1、 Eiden,Meins. "Synthesis of 1,2-biscoumarinylethene derivatives". . p. 124 - 134. Retrieved 2007/10/05.