Thieno[2,3-b]pyridine-5-carboxamide

Base Information

• Chemical Name: Thieno[2,3-b]pyridine-5-carboxamide
• CAS No.: 117390-40-6
• Molecular Formula: C8H6N2OS
• Molecular Weight: 178.214
• Mol file: 117390-40-6.mol

Synonyms:

Chemical Property of Thieno[2,3-b]pyridine-5-carboxamide

Chemical Property:

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thieno[2,3-b]pyridine-5-carboxamide

There total 1 articles about Thieno[2,3-b]pyridine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-acetyl thieno<2,3-b>pyridine (18354-57-9) → 5-carbamoyl thieno<2,3-b>pyridine (117390-40-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / Br₂, NaOH / H₂O / 12 h / Ambient temperature

2: 1.) thionyle chloride; 2.) NH₃ / 1.) reflux, 12 h; 2.) CH₂Cl₂, 0 deg C, 2 h

With sodium hydroxide; thionyl chloride; ammonia; bromine; In water;

DOI:10.1016/S0040-4020(01)85888-9

Reference yield: 100.0%

nitrostyrene (5153-67-3) + 5-carbamoyl thieno<2,3-b>pyridine (117390-40-6) + bromo-8 octyl dimethylchlorosilane (125056-17-9) → 2-Phenylnitroethane (6125-24-2)

Guidance literature:

With magnesium(II) perchlorate; silice (Merck Kieselgel Art_.:7734); Product distribution; multistep reaction; 1.) grafting on a silica matrix, reflux, in toluene, 12 h, 2.) reflux, toluene, 5 days. 3.) acetonitrile, 65 deg C, 5 days; reagent quqntity, reaction time varied;

Reference yield:

1-bromo-4-butene (5162-44-7) + dimethylmonochlorosilane (1066-35-9) + 4-nitrobenzaldehdye (555-16-8) + 5-carbamoyl thieno<2,3-b>pyridine (117390-40-6) → 4-nitrobenzyl chloride (619-73-8)

Guidance literature:

With magnesium(II) perchlorate; silice (Merck Kieselgel Art_.:7734); Product distribution; multistep reaction; 1.) grafting on a silica, reflux, in toluene, 12 h, 2.) quaternerisation, reflux, toluene, 5 days, 3.) acetonitrile, 65 deg C, 5 days; reagent quantity, reaction time varied;

upstream raw materials:

5-acetyl thieno<2,3-b>pyridine

Downstream raw materials:

2-Phenylnitroethane

4-nitrobenzyl chloride

Refernces