4-[2-(aminooxy)ethyl]morpholine dihydrochloride

Base Information

• Chemical Name: 4-[2-(aminooxy)ethyl]morpholine dihydrochloride
• CAS No.: 1195-51-3
• Molecular Formula: C₆H₁₄N₂O₂*2ClH
• Molecular Weight: 219.111
• Mol file: 1195-51-3.mol

Synonyms:

Chemical Property of 4-[2-(aminooxy)ethyl]morpholine dihydrochloride

Chemical Property:

• Vapor Pressure: 0.000114mmHg at 25°C

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[2-(aminooxy)ethyl]morpholine dihydrochloride

There total 10 articles about 4-[2-(aminooxy)ethyl]morpholine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(2-morpholinoethoxy)isoindoline-1,3-dione → O-(2-morpholinoethyl)hydroxylamine dihydrochloride (1195-51-3,72423-24-6,80366-57-0)

Guidance literature:

2-(2-morpholinoethoxy)isoindoline-1,3-dione; With hydrazine hydrate; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

With hydrogenchloride; In diethyl ether; Inert atmosphere;

DOI:10.1021/ja211305j

Reference yield: 78.0%

(2-Morpholin-4-yl-ethoxy)-carbamic acid tert-butyl ester (606143-97-9) → O-(2-morpholinoethyl)hydroxylamine dihydrochloride (1195-51-3,72423-24-6,80366-57-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 20h;

Reference yield: 63.0%

benzophenone O-(2-morpholin-4-yl-ethyl)-oxime (98883-94-4) → O-(2-morpholinoethyl)hydroxylamine dihydrochloride (1195-51-3,72423-24-6,80366-57-0)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 2h; Heating / reflux;

upstream raw materials:

propan-2-one O-2-morpholinoethyl oxime

benzophenone O-(2-morpholin-4-yl-ethyl)-oxime

N-(2-chlorethyl)morpholine

4-(2-chloroethyl)morpholine hydrochride

Downstream raw materials:

2,6-Dimethyl-5-{1-[(E)-2-morpholin-4-yl-ethoxyimino]-ethyl}-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid methyl ester

JNJ-28871063

(2,3-Dichloro-4-methoxy)-phenyl 2-thienyl O-(morpholinoethyl)-ketone oxime

Refernces

• 1、 Deraeve, Celine,Guo, Zhong,Bon, Robin S.,Blankenfeldt, Wulf,DiLucrezia, Raffaella,Wolf, Alexander,Menninger, Sascha,Stigter, E. Anouk,Wetzel, Stefan,Choidas, Axel,Alexandrov, Kirill,Waldmann, Herbert,Goody, Roger S.,Wu, Yao-Wen. "Psoromic acid is a selective and covalent rab-prenylation inhibitor targeting autoinhibited rabggtase". . p. 7384 - 7391. Retrieved 2012/06/30.
• 2、 Gaul, Micheal D.,Xu, Guozhang,Kirkpatrick, Jennifer,Ott, Heidi,Baumann, Christian A.. "4-Amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes as potent FLT-3 inhibitors". . p. 4861 - 4865. Retrieved 2008/02/12.