5E-4-Amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehydeN-(2-morpholin-4-ylethyl)oximehydrochloride

Base Information

• Chemical Name: 5E-4-Amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehydeN-(2-morpholin-4-ylethyl)oximehydrochloride
• CAS No.: 944341-54-2
• Molecular Formula: C₂₄H₂₇ClN₆O₃
• Molecular Weight: 482.97
• Mol file: 944341-54-2.mol

Synonyms:5E-4-Amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehydeN-(2-morpholin-4-ylethyl)oximehydrochloride;JNJ 28871063 hydrochloride

Chemical Property of 5E-4-Amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehydeN-(2-morpholin-4-ylethyl)oximehydrochloride

Chemical Property:

• PSA: 107.12000
• LogP: 5.11160
• Storage Temp.: Desiccate at +4°C

Purity/Quality:

99%min ^*data from raw suppliers

JNJ 28871063 Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: JNJ 28871063 hydrochloride is a potent inhibitor of ErbB receptors.

Technology Process of 5E-4-Amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehydeN-(2-morpholin-4-ylethyl)oximehydrochloride

There total 2 articles about 5E-4-Amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehydeN-(2-morpholin-4-ylethyl)oximehydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbaldehyde oxime + 4-(2-chloroethyl)morpholine hydrochride (3647-69-6) → JNJ-28871063 (944341-54-2)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 6h; Product distribution / selectivity;

Reference yield: 81.0%

4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbaldehyde (944342-88-5) + O-(2-morpholinoethyl)hydroxylamine dihydrochloride (1195-51-3,72423-24-6,80366-57-0) → JNJ-28871063 (944341-54-2)

Guidance literature:

With sodium hydroxide; In water; at 20 - 115 ℃; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbaldehyde

O-(2-morpholinoethyl)hydroxylamine dihydrochloride

4-(2-chloroethyl)morpholine hydrochride

Refernces