Technology Process of L-Proline, 1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-,
1,1-dimethylethyl ester, (R)-
There total 6 articles about L-Proline, 1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-,
1,1-dimethylethyl ester, (R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonium carbonate;
In
nitromethane; water;
at 50 ℃;
for 96h;
DOI:10.1248/cpb.37.280
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 45 percent / methanol; H2O / 8 h / 70 °C
2: 99.3 percent / NH4Cl / aq. NH3 / 50 h / 37 °C / enzymatic hydrolysis with Pseudomonas putida at pH 9
3: 1.) NaNO2, 2N H2SO4; 2.) KBr, NaNO2, 3N H2SO4 / 1.) 50percent CH3COOH, r.t., 24 h; 2.) 50percent CH3COOH, 0-5 deg C, 1 h
4: 95 percent / SOCl2 / 24 h / Ambient temperature
5: 7.5 percent / (NH4)2CO3 / nitromethane; H2O / 96 h / 50 °C
With
thionyl chloride; sulfuric acid; ammonium carbonate; ammonium chloride; potassium bromide; sodium nitrite;
In
methanol; ammonium hydroxide; nitromethane; water;
DOI:10.1248/cpb.37.280
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 99.3 percent / NH4Cl / aq. NH3 / 50 h / 37 °C / enzymatic hydrolysis with Pseudomonas putida at pH 9
2: 1.) NaNO2, 2N H2SO4; 2.) KBr, NaNO2, 3N H2SO4 / 1.) 50percent CH3COOH, r.t., 24 h; 2.) 50percent CH3COOH, 0-5 deg C, 1 h
3: 95 percent / SOCl2 / 24 h / Ambient temperature
4: 7.5 percent / (NH4)2CO3 / nitromethane; H2O / 96 h / 50 °C
With
thionyl chloride; sulfuric acid; ammonium carbonate; ammonium chloride; potassium bromide; sodium nitrite;
In
ammonium hydroxide; nitromethane; water;
DOI:10.1248/cpb.37.280