Technology Process of 5-Methoxy-2-phenyl-2H-indazole
There total 23 articles about 5-Methoxy-2-phenyl-2H-indazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium methanolate;
In
N,N-dimethyl-formamide;
at 90 ℃;
for 8h;
Inert atmosphere;
Schlenk technique;
DOI:10.1039/d0cc05862a
- Guidance literature:
-
5-methoxy-1-acetyl-2-phenyldihydroindazole;
With
sodium hydroxide;
In
methanol;
at 70 ℃;
for 0.5h;
With
oxygen;
In
dichloromethane;
Further stages.;
- Guidance literature:
-
2-bromo-5-methoxybenzyl bromide; phenylhydrazine;
With
caesium carbonate;
In
dimethyl sulfoxide;
at 20 ℃;
for 3h;
Inert atmosphere;
Sealed tube;
With
caesium carbonate; palladium dichloride; tri tert-butylphosphoniumtetrafluoroborate;
In
dimethyl sulfoxide;
at 120 ℃;
for 18h;
regioselective reaction;
Inert atmosphere;
Sealed tube;
DOI:10.1021/acs.joc.0c01923