19614-12-1

Basic information

• Product Name: 2-BROMO-5-METHOXYBENZYL BROMIDE 97
• Synonyms: 2-BROMO-5-METHOXYBENZYL BROMIDE 97;4-Bromo-3-bromomethyl anisole;5-BroMo-2-Methoxy Benzyl BroMide;2-Bromo-5-methyoxybenzyl bromide;2-Bromo-5-methoxybenzyl bromide 97%
• CAS NO: 19614-12-1
• Molecular Formula: C₈H₈Br₂O
• Molecular Weight: 279.958
• Product Categories: Ethers;Organic Building Blocks;Oxygen Compounds;Building Blocks;C2 to C8;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;alkyl bromide
• Mol File: 19614-12-1.mol
• Article Data: 45

Chemical Properties

• Melting Point: 90-94 °C(lit.)
• Boiling Point: 299.6 °C at 760 mmHg
• Flash Point: 120.3 °C
• Appearance: White to beige/Solid
• Density: 1.759 g/cm³
• Vapor Pressure: 0.0021mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility: Soluble in hot methanol. Slightly soluble in water.
• CAS DataBase Reference: 2-BROMO-5-METHOXYBENZYL BROMIDE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-5-METHOXYBENZYL BROMIDE 97(19614-12-1)
• EPA Substance Registry System: 2-BROMO-5-METHOXYBENZYL BROMIDE 97(19614-12-1)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: Ⅱ
• Hazardous Substances Data: 19614-12-1(Hazardous Substances Data)

Usage

Description

2-BROMO-5-METHOXYBENZYL BROMIDE 97, also known as 2,5-dibromobenzyl bromide, is an organic compound with the molecular formula C7H6Br2O2. It is a brominated aromatic compound characterized by the presence of two bromine atoms and a methoxy group attached to a benzene ring. This chemical structure endows it with unique properties and reactivity, making it a versatile building block in various chemical syntheses.

Uses

Used in Organic Synthesis:
2-BROMO-5-METHOXYBENZYL BROMIDE 97 is used as an important intermediate for the synthesis of various organic compounds. Its unique structure allows for further functionalization and modification, making it a valuable precursor in the development of new molecules with potential applications in various fields.
Used in Agrochemicals:
In the agrochemical industry, 2-BROMO-5-METHOXYBENZYL BROMIDE 97 is used as a key intermediate for the production of various pesticides and other agricultural chemicals. Its reactivity and structural features enable the development of compounds with improved efficacy, selectivity, and environmental compatibility.
Used in Pharmaceutical Industry:
2-BROMO-5-METHOXYBENZYL BROMIDE 97 plays a crucial role in the pharmaceutical industry as an intermediate for the synthesis of various drugs and drug candidates. Its unique chemical properties allow for the development of novel therapeutic agents with potential applications in the treatment of various diseases and medical conditions.
Used in Dye Industry:
In the dyestuff industry, 2-BROMO-5-METHOXYBENZYL BROMIDE 97 is employed as a starting material for the synthesis of various dyes and pigments. Its structural features contribute to the development of dyes with improved color properties, stability, and performance characteristics, making it an essential component in the production of high-quality dyes for various applications.

InChI:InChI=1/C8H8Br2O/c1-11-7-2-3-8(10)6(4-7)5-9/h2-4H,5H2,1H3

Upstream product

• 150192-39-5 2-Bromo-5-methoxybenzyl alcohol 
• 128-08-5 N-Bromosuccinimide 
• 100-84-5 1-methoxy-3-methyl-benzene 
• 27060-75-9 4-bromo-3-methylanisole 
• 77-48-5 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione 
• 591-31-1 3-methoxy-benzaldehyde 
• 874-98-6 1-bromomethyl-3-methoxybenzene 

Downstream Products

• 155854-95-8 Ethyl 3-(5-methoxy-2-bromobenzyl)-2-methyl-4-oxocyclohex-2-enecarboxylate 
• 147085-54-9 2-<(2-bromo-5-methoxyphenyl)methyl>cyclohexanone 
• 200346-53-8 (3aR,5R,6S,6aR)-6-(2-bromo-5-methoxybenzyloxy)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxole 
• 220429-84-5 dimethyl [(2-bromo-5-methoxyphenyl)methyl]phosphonate 
• 149244-21-3 1-bromo-2-(but-3-en-1-yl)-4-methoxybenzene 
• 855300-81-1 3-(2-bromo-5-methoxy-benzyloxy)-1-methyl-1H-quinolin-2-one 
• 262364-69-2 N-(2-bromo-5-methoxy-benzyl)-N-phenyl-hydrazine 
• 953424-03-8 C₁₆H₁₃BrO₂S 
• 776298-25-0 5'-[(E)-2-(4-Benzyloxy-3-methoxy-phenyl)-vinyl]-5-[(E)-2-(2-bromo-5-methoxy-phenyl)-vinyl]-2,2'-dimethoxy-biphenyl 
• 776298-22-7 trifluoro-methanesulfonic acid 4-(2-{5'-[2-(2-bromo-5-methoxy-phenyl)-ethyl]-6,2'-dimethoxy-biphenyl-3-yl}-ethyl)-2-methoxy-phenyl ester 
• 776298-34-1 trifluoro-methanesulfonic acid 4-[2-(6,2'-dimethoxy-5'-{2-[5-methoxy-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethyl}-biphenyl-3-yl)-ethyl]-2-methoxy-phenyl ester 
• 928637-43-8 N-(2-bromo-5-methoxybenzyl)-N-(5-fluoro-2-phenoxyphenyl)acetamide 

Relevant articles and documents

Halogenolysis of Benzylcobaloximes

The reaction of substituted benzylcobaloximes p-RC6H4Co(dmgH)2-Py (R=OMe, NHCOCH3 and NMe2) and m-RC6H4CH2Co(dmgH)2Py (R=Me, OMe) with halogens (Cl2 and Br2) in chloroform under nitrogen forms ring substituted organic and organometallic products.

Discovery of orally active nonpeptide vitronectin receptor antagonists based on a 2-benzazepine Gly-Asp mimetic [2]

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Stereoselective Convergent Synthesis of Tetrahydro-5 H-benzo[c]fluorene via Nine-Membered Ring-Closing Metathesis and Transannular Acid-Mediated Cyclization/Nucleophilic Addition

The diene methyl ethers or acetates, constructed from the Li-Br exchange/addition reactions of 2-vinylbenzaldehydes and 2-(but-3-en-1-yl)bromoarenes followed by etherification or acetylation of the corresponding alcohols, smoothly underwent the ring-closi

CATALYSTS

A catalyst comprising (i) an asymmetric complex of formula (I) wherein M is zirconium or hafnium; each X is a sigma ligand; L is a divalent bridge selected from —R′2C—, —R′2C—CR′2—, —R′2Si—, —R′2Si—SiR′2—, —R′2Ge—, wherein each R′ is independently a hydrogen atom, C1-C20-alkyl, tri(C1-C20-alkyl)silyl, C6-C20-aryl, C7-C20-arylalkyl or C7-C20-alkylaryl; R2 and R2′ are each independently linear C1-10 hydrocarbyl; R5 and R5′ are each independently hydrogen or a C1-20 hydrocarbyl group; R6 and R6′ are each independently hydrogen or a C1-20 hydrocarbyl group; R7 is hydrogen or a C1-20 hydrocarbyl group or is ZR3; Z is O or S, preferably O; R3 is a C1-10 hydrocarbyl group; Ar is an aryl or heteroaryl group having up to 20 carbon atoms optionally substituted by one or more groups R8; Ar′ is an aryl or heteroaryl group having up to 20 carbon atoms optionally substituted by one or more groups R8′; and R8 and R8′ are each independently is a C1-20 hydrocarbyl group; with the proviso that at least one of R6 or R7 is not H; and (ii) a cocatalyst comprising a compound of a group 13 metal, e.g. boron.