200346-53-8

Basic information

• Product Name: (3aR,5R,6S,6aR)-6-(2-bromo-5-methoxybenzyloxy)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxole
• Synonyms: (3aR,5R,6S,6aR)-6-(2-bromo-5-methoxybenzyloxy)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxole
• CAS NO: 200346-53-8
• Molecular Weight: 459.334
• Mol File: 200346-53-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (3aR,5R,6S,6aR)-6-(2-bromo-5-methoxybenzyloxy)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxole(CAS DataBase Reference)
• NIST Chemistry Reference: (3aR,5R,6S,6aR)-6-(2-bromo-5-methoxybenzyloxy)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxole(200346-53-8)
• EPA Substance Registry System: (3aR,5R,6S,6aR)-6-(2-bromo-5-methoxybenzyloxy)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxole(200346-53-8)

Safety Data

• Hazardous Substances Data: 200346-53-8(Hazardous Substances Data)

Upstream product

• 19614-12-1 2-bromo-5-methoxybenzyl bromide 
• 582-52-5 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 

Downstream Products

• 866890-75-7 (3aR,5S,6R,6aR)-6-(2-bromo-5-methoxy-benzyloxy)-5-iodomethyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxole 
• 1030614-10-8 (3aR,5R,6S,6aR)-[6-(2-bromo-5-methoxybenzyloxy)-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxol-5-yl]methanol 
• 866890-78-0 (3aR,6R,6aR)-6-(2-bromo-5-methoxy-benzyloxy)-2,2-dimethyl-5-methylene-tetrahydro-furo[2,3-d][1,3]dioxole 
• 200346-55-0 (R)-1-[(3aR,5R,6S,6aR)-6-(2-Bromo-5-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-ethane-1,2-diol 

Relevant articles and documents

Palladium-catalyzed intramolecular C-O bond formation: An approach to the synthesis of chiral benzodioxocines

Palladium-catalyzed intramolecular aryl etherification using bulky binaphthylphosphane or bis(diphenylphosphanyl)ferrocene ligands is shown to be a convenient method for the synthesis of eight-membered oxygen heterocycles. Application of this methodology to a sugar derivative led to the synthesis of chiral benzodioxocine. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

Synthesis of chiral cis- and trans-furo[3,2-c][2]benzoxocines from D-glucose by regioselective 8-endo aryl radical cyclisation

A simple chiral synthesis of cis- and trans-furo[3,2-c][2]benzoxocines 8a-d and 9a-d through a regioselective 8-endo-trig aryl radical cyclisation of the respective 5,6-dideoxy-D-xylo-hex-5-enofuranosides 6a-d and 5,6-dideoxy-D-ribo-hex-5-enofuranosides 7