6-bromocatechin

Base Information

• Chemical Name: 6-bromocatechin
• CAS No.: 88488-99-7
• Molecular Formula: C₁₅H₁₃BrO₆
• Molecular Weight: 369.169
• Mol file: 88488-99-7.mol

Synonyms:

Chemical Property of 6-bromocatechin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-bromocatechin

There total 5 articles about 6-bromocatechin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6,8-dibromocatechin (88038-00-0,88488-98-6,105815-57-4) → 6-bromocatechin (88038-02-2,88488-99-7,105815-61-0) + catechin (154-23-4,490-46-0,7295-85-4,17334-50-8,18829-70-4,35323-91-2,72690-97-2,13392-26-2)

Guidance literature:

With sodium sulfite; In [D₃]acetonitrile; water-d2; for 2.26667h; Product distribution; study of the debromination reaction, mechanism is dicussed;

Reference yield:

catechin (154-23-4) → 6-bromo-(+)-catechin (88488-99-7)

Guidance literature:

With pyridinium hydrobromide perbromide; In acetonitrile; at 0 ℃; for 0.5h; Yield given;

DOI:10.1248/cpb.33.4338

Reference yield:

epicatechin-(2β->O->7, 4β->8)-epicatechin-(4β->8)-catechin (97233-06-2) → 6-bromo-(+)-catechin (88488-99-7)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / ethanol / 13 h / Heating

2: pyridinium hydrobromide perbromide / acetonitrile / 0.5 h / 0 °C

With pyridinium hydrobromide perbromide; acetic acid; In ethanol; acetonitrile;

DOI:10.1248/cpb.33.4338

upstream raw materials:

catechin

epicatechin-(2β->O->7, 4β->8)-epicatechin-(4β->8)-catechin

cinnamtannin D₂

6,8-dibromocatechin

Downstream raw materials:

6-bromo-8-iodocatechin

6-bromo-3-O-acetyl-3',4',5,7-tetra-O-methyl-(+)-catechin

6-bromo-3,3',4',5,7-penta-O-acetyl-(+)-catechin

C₄₅H₃₅BrO₁₈

Refernces

• 1、 Morimoto,Nonaka,Nishioka. "Tannins and related compounds. XXXV. Proanthocyanidins with a doubly linked unit from the root bark of Cinnamomum sieboldii Meisner". . p. 4338 - 4345. Retrieved 2007/10/02.