Benzyl 2-aminopropanoate hydrochloride

Base Information

• Chemical Name: Benzyl 2-aminopropanoate hydrochloride
• CAS No.: 5557-81-3
• Molecular Formula: C₁₀H₁₃NO₂*ClH
• Molecular Weight: 215.68
• European Community (EC) Number: 226-920-4,833-377-2
• NSC Number: 523831
• Mol file: 5557-81-3.mol

Synonyms:benzyl 2-aminopropanoate hydrochloride;5557-81-3;H-DL-Ala-Obzl.HCl;benzyl 2-aminopropanoate;hydrochloride;Benzyl L-alaninate hydrochloride;MFCD00054340;SCHEMBL1764407;NSC523831;AKOS024386244;NSC-523831;SY029626;CS-0231697;FT-0659578;EN300-109484;Z2472775311;(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINEMALEATESALT

Chemical Property of Benzyl 2-aminopropanoate hydrochloride

Chemical Property:

• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 215.0713064
• Heavy Atom Count: 14
• Complexity: 164

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)OCC1=CC=CC=C1)N.Cl

Technology Process of Benzyl 2-aminopropanoate hydrochloride

There total 12 articles about Benzyl 2-aminopropanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(tert-butoxycarbonyl)-L-alanine benzyl ester (126400-95-1,51814-54-1) → L-alanine benzyl ester hydrochloride (5557-81-3,5557-83-5,34404-37-0)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 2h;

DOI:10.1021/jo070412r

Reference yield: 95.0%

D-Alanine (338-69-2,25191-17-7,18875-37-1) + benzyl alcohol (100-51-6,185532-71-2) → (R)-benzyl 2-aminopropanoate hydrochloride (5557-81-3,5557-83-5,34404-37-0)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃;

DOI:10.1055/s-0029-1216837

Reference yield: 82.0%

L-alanin (56-41-7,25191-17-7,18875-37-1) + benzyl alcohol (100-51-6,185532-71-2) → L-alanine benzyl ester hydrochloride (5557-81-3,5557-83-5,34404-37-0)

Guidance literature:

With thionyl chloride; at 0 ℃; Reflux;

DOI:10.1021/acsmedchemlett.6b00270

upstream raw materials:

chloro-trimethyl-silane

L-alanin

benzyl alcohol

N-(tert-butoxycarbonyl)-L-alanine benzyl ester

Downstream raw materials:

N-(N-benzyloxycarbonyl-L-α-glutamyl)-L-alanine benzyl ester

N-((tert-butoxycarbonyl)-L-leucyl)-L-alanine benzyl ester

Boc-Arg(NO₂)-Ala-OBzl

(S)-2-(2,2,5,5-Tetramethyl-[1,2,5]azadisilolidin-1-yl)-propionic acid benzyl ester

Refernces

• 1、 -. "4'-THIO-NUCLEOTIDE AND -NUCLEOSIDE PRODRUGS FOR THE TREATMENT OF CANCER". Paragraph 00423. . Retrieved 2019/11/12.
• 2、 Saikiran, Maryala,Sato, Daisuke,Pandey, Shyam S.,Hayase, Shuzi,Kato, Tamaki. "Efficient near infrared fluorescence detection of elastase enzyme using peptide-bound unsymmetrical squaraine dye". supporting information. p. 4024 - 4029. Retrieved 2017/08/23.