2,2-DICHLORO-1-PHENYL-CYCLOPROPANECARBALDEHYDE

Base Information

• Chemical Name: 2,2-DICHLORO-1-PHENYL-CYCLOPROPANECARBALDEHYDE
• CAS No.: 122801-51-8
• Molecular Formula: C10H8Cl2O
• Molecular Weight: 215.079
• Mol file: 122801-51-8.mol

Synonyms:2,2-dichloro-1-phenylcyclopropanecarbaldehyde;

Chemical Property of 2,2-DICHLORO-1-PHENYL-CYCLOPROPANECARBALDEHYDE

Chemical Property:

• PSA: 17.07000
• LogP: 2.70090

Purity/Quality:

98%min ^*data from raw suppliers

2,2-Dichloro-1-phenyl-cyclopropanecarbaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-DICHLORO-1-PHENYL-CYCLOPROPANECARBALDEHYDE

There total 2 articles about 2,2-DICHLORO-1-PHENYL-CYCLOPROPANECARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2,2-dichloro-1-phenylcyclopropanecarbaldehyde diethyl acetal (156020-80-3) → 2,2-dichloro-1-phenylcyclopropane-1-carbaldehyde (122801-51-8)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 60 ℃; for 8h;

DOI:10.1039/P19940000739

Reference yield:

2-phenylacrylaldehyde diethyl acetal (80234-04-4) → 2,2-dichloro-1-phenylcyclopropane-1-carbaldehyde (122801-51-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / NaOH, benzyltriethylammonium chloride / CH₂Cl₂; H₂O / 2 h / 40 °C

2: 74 percent / conc. HCl / tetrahydrofuran; H₂O / 8 h / 60 °C

With hydrogenchloride; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In tetrahydrofuran; dichloromethane; water;

DOI:10.1039/P19940000739

Reference yield: 75.0%

2,2-dichloro-1-phenylcyclopropane-1-carbaldehyde (122801-51-8) + N-(4-chlorophenyl)hydroxylamine (823-86-9) → 4-chloro-N-(2,2-dichloro-1-phenylcyclopropylmethylidene)aniline N-oxide (1283128-84-6)

Guidance literature:

In ethanol; at 4 ℃;

DOI:10.1134/S1070428011010076

upstream raw materials:

2,2-dichloro-1-phenylcyclopropanecarbaldehyde diethyl acetal

2-phenylacrylaldehyde diethyl acetal

Downstream raw materials:

[1-(2,2-Dichloro-1-phenyl-cyclopropyl)-meth-(E)-ylidene]-thiophen-2-ylmethyl-amine

N-(2,2-dichloro-1-phenylcyclopropylmethylene)-α,α-dideuteriobenzylamine

[1-(2,2-Dichloro-1-phenyl-cyclopropyl)-meth-(E)-ylidene]-naphthalen-1-ylmethyl-amine

Butyl-[1-(2,2-dichloro-1-phenyl-cyclopropyl)-meth-(E)-ylidene]-amine

Refernces