(2R,4R)-2,4-dimethylpentanedioic acid

Base Information

• Chemical Name: (2R,4R)-2,4-dimethylpentanedioic acid
• CAS No.: 3891-69-8
• Molecular Formula: C₇H₁₂O₄
• Molecular Weight: 160.17
• Mol file: 3891-69-8.mol

Synonyms:

Chemical Property of (2R,4R)-2,4-dimethylpentanedioic acid

Chemical Property:

• Vapor Pressure: 0.000264mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4R)-2,4-dimethylpentanedioic acid

There total 17 articles about (2R,4R)-2,4-dimethylpentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.8%

(+/-)-anti-2,4-dimethylglutaric anhydride (4295-92-5,7446-84-6,35878-31-0,50901-09-2,82950-73-0,118139-25-6) → DL-2,4-dimethylglutaric acid (3891-69-8)

Guidance literature:

In water; for 2h; Heating;

DOI:10.1002/1099-0690(200102)2001:3<493::AID-EJOC493>3.0.CO;2-B

Reference yield:

methyl-malonic acid dimethylester (609-02-9) + methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → meso-2,4-dimethylpentane-1,5-diol (3891-70-1) + DL-2,4-dimethylglutaric acid (3891-69-8)

Guidance literature:

methyl-malonic acid dimethylester; With sodium methylate; In methanol; at 20 ℃; Inert atmosphere;

methacrylic acid methyl ester; With acetic acid; In methanol; at 20 ℃; pH=7; Inert atmosphere;

With hydrogenchloride; acetic acid; In water; for 25h; Inert atmosphere; Reflux;

DOI:10.1021/ol2017802

Reference yield:

→ DL-2,4-dimethylglutaric acid (3891-69-8)

Guidance literature:

With hydrogen iodide; at 130 - 135 ℃;

upstream raw materials:

2,4-dicyano-2-methyl-valeric acid ethyl ester

4,6-dimethyl-1,3-cyclohexanedione

(+/-)-dimethyl trans-2,4-dimethylglutarate

ethyl 2-bromoisovalerate

Downstream raw materials:

CGS 13934

1-<(2R,4R)-4-(ethoxycarbonyl)-2,4-dimethylbutyryl>indoline-2(S)-carboxylic acid

(2R,4R)-2,4-dimethylpentanolide

(+/-)-anti-2,4-dimethylglutaric anhydride

Refernces

• 1、 Fotiadou, Anna D.,Zografos, Alexandros L.. "Accessing the structural diversity of pyridone alkaloids: Concise total synthesis of rac-citridone A". supporting information; experimental part. p. 4592 - 4595. Retrieved 2011/10/17.