3,5-Dibromo-4-ethylpyridine

Base Information

• Chemical Name: 3,5-Dibromo-4-ethylpyridine
• CAS No.: 125419-80-9
• Molecular Formula: C7H7Br2N
• Molecular Weight: 264.947
• Mol file: 125419-80-9.mol

Synonyms:3,5-Dibromo-4-ethyl-pyridine;

Chemical Property of 3,5-Dibromo-4-ethylpyridine

Chemical Property:

• Boiling Point: 259oC
• Flash Point: 110oC
• PSA: 12.89000
• Density: 1.792
• LogP: 3.16900

Purity/Quality:

98%Min ^*data from raw suppliers

3,5-Dibromo-4-ethylpyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Dibromo-4-ethylpyridine

There total 3 articles about 3,5-Dibromo-4-ethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3,5-dibromopyridine (625-92-3) + ethyl iodide (75-03-6) → 3,5-dibromo-4-ethylpyridine (125419-80-9)

Guidance literature:

3,5-dibromopyridine; With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

ethyl iodide; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm2016107

Reference yield: 8.0%

4-Ethylpyridine (536-75-4,151103-55-8) → 3-bromo-4-ethyl pyridine (38749-76-7) + 3,5-dibromo-4-ethylpyridine (125419-80-9)

Guidance literature:

With sulfuric acid; bromine; at 70 - 80 ℃;

Reference yield:

3,5-dibromopyridine (625-92-3) + methyl iodide (74-88-4) → 3,5-dibromo-4-methyl-pyridine (3430-23-7) + 3,5-dibromo-4-ethylpyridine (125419-80-9)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, -78 deg C, 5 min; 2.) THF, -78 deg C, excess MeI;

DOI:10.1016/0040-4039(96)00331-0

upstream raw materials:

4-Ethylpyridine

3,5-dibromopyridine

methyl iodide

ethyl iodide

Downstream raw materials:

(5-bromo-4-ethylpyridin-3-yl)boronic acid

3-(5-bromo-4-ethylpyridin-3-yl)-5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazole

3-(5-bromo-4-ethylpyridin-3-yl)-5-(3-chloro-4-isopropoxyphenyl)-1,2,4-thiadiazole

5-(3-(5-bromo-4-ethylpyridin-3-yl)-1,2,4-thiadiazol-5-yl)-2-isobutylbenzonitrile

Refernces

• 1、 -. "ISOQUINOLINES AS INHIBITORS OF HPK1". Paragraph 0778; 0779. . Retrieved 2018/10/21.
• 2、 Dunn, Allan D.,Blais, Mickael. "The Bromination of Pyridines; - The Bromination of Ethylated Pyridines and Higher Homologues". . p. 287 - 288. Retrieved 2007/10/02.