Technology Process of (S)-3-((R)-4-Benzoylamino-4-dipropylcarbamoyl-butyrylamino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid
There total 14 articles about (S)-3-((R)-4-Benzoylamino-4-dipropylcarbamoyl-butyrylamino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) NEt3, ethyl chloroformate / 1.) THF, -15 - 0 deg C, 10 min, 2.) THF, -10 - 0 deg C, 6 h
2: 1N NaOH / tetrahydrofuran / 2 h / Ambient temperature
3: 1.) ethyl chloroformate, NEt3, 2.) NEt3 / 1.) THF, -15- -10 deg C, 10 min, 2.) THF, H2O, -5- 0 deg C, 5 h
4: H2 / 10percent Pd-C / dioxane; aq. HCl / 2 h / Ambient temperature
5: NaHCO3 / H2O; diethyl ether / 3 h
With
sodium hydroxide; hydrogen; chloroformic acid ethyl ester; sodium hydrogencarbonate; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; hydrogenchloride; diethyl ether; water;
DOI:10.1248/cpb.36.3433
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) NEt3, ethyl chloroformate / 1.) THF, -15 - 0 deg C, 10 min, 2.) THF, -10 - 0 deg C, 6 h
2: 1N NaOH / tetrahydrofuran / 2 h / Ambient temperature
3: 1.) ethyl chloroformate, NEt3, 2.) NEt3 / 1.) THF, -15- -10 deg C, 10 min, 2.) THF, H2O, -5- 0 deg C, 5 h
4: H2 / 10percent Pd-C / dioxane; aq. HCl / 2 h / Ambient temperature
5: NaHCO3 / H2O; diethyl ether / 3 h
With
sodium hydroxide; hydrogen; chloroformic acid ethyl ester; sodium hydrogencarbonate; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; hydrogenchloride; diethyl ether; water;
DOI:10.1248/cpb.36.3433
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) paraformaldehyde, p-toluenesulfonic acid hydrate / 1.) benzene, 2.) THF, reflux, 8 h
2: 1.) ethyl chloroformate, NEt3, 2.) NEt3 / 1.) THF, -15- -10 deg C, 10 min, 2.) THF, H2O, -5- 0 deg C, 5 h
3: H2 / 10percent Pd-C / dioxane; aq. HCl / 2 h / Ambient temperature
4: NaHCO3 / H2O; diethyl ether / 3 h
With
formaldehyd; hydrogen; chloroformic acid ethyl ester; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine;
palladium on activated charcoal;
In
1,4-dioxane; hydrogenchloride; diethyl ether; water;
DOI:10.1248/cpb.36.3433