DL-2-Chlorophenylglycinol

Base Information

• Chemical Name: DL-2-Chlorophenylglycinol
• CAS No.: 127428-62-0
• Molecular Formula: C8H10ClNO
• Molecular Weight: 171.626
• Hs Code.: 2922190090
• Mol file: 127428-62-0.mol

Synonyms:b-Amino-2-chlorobenzeneethanol;amino-(2,3-dichlorophenyl)acetic acid;2-amino-2-(2-chlorophenyl)-ethanol;

Chemical Property of DL-2-Chlorophenylglycinol

Chemical Property:

• Boiling Point: 318.7±27.0 °C(Predicted)
• PKA: 12.36±0.10(Predicted)
• PSA: 46.25000
• Density: 1.260±0.06 g/cm3(Predicted)
• LogP: 2.03240

Purity/Quality:

97% ^*data from raw suppliers

2-amino-2-(2-chlorophenyl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of DL-2-Chlorophenylglycinol

There total 7 articles about DL-2-Chlorophenylglycinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-amino-(2-chlorophenyl)ethanoic acid (86169-24-6,141196-64-7,141315-50-6,88744-36-9) → 2-amino-2-(2-chlorophenyl)ethan-1-ol (127428-62-0)

Guidance literature:

2-amino-(2-chlorophenyl)ethanoic acid; With borane-THF; In tetrahydrofuran; at 20 ℃; Inert atmosphere; Cooling with ice bath;

With water; sodium hydroxide; In tetrahydrofuran;

Reference yield:

C10H7Cl4NO → 2-amino-2-(2-chlorophenyl)ethan-1-ol (127428-62-0)

Guidance literature:

With hydrogenchloride; In methanol; water; for 2h;

DOI:10.1021/jacs.7b05214

Reference yield:

2-chlorophenethyl 2,2,2-trichloroacetimidate → 2-amino-2-(2-chlorophenyl)ethan-1-ol (127428-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium iodide; [bis(acetoxy)iodo]benzene / acetonitrile / 2 h / Irradiation; Inert atmosphere

2: hydrogenchloride / methanol; water / 2 h

With hydrogenchloride; [bis(acetoxy)iodo]benzene; sodium iodide; In methanol; water; acetonitrile;

DOI:10.1021/jacs.7b05214

upstream raw materials:

2-amino-(2-chlorophenyl)ethanoic acid

2-(2-chlorophenyl)-1-ethanol

2-chloro-benzaldehyde

o-chlorostyrene oxide

Downstream raw materials:

2-(2-chlorophenyl)-4-(2-chlorophenyl)-2-oxazoline

(E)-1-(2-chlorophenyl)-N-(4-methoxyphenyl)methanimine

Refernces

• 1、 Fang, Yuanding,Fu, Kang,Shi, Lei,Zhao, Rong,Zhou, Jia. "Site-Specific C(sp3)–H Aminations of Imidates and Amidines Enabled by Covalently Tethered Distonic Radical Anions". supporting information. p. 20682 - 20690. Retrieved 2020/09/07.
• 2、 Kim, Seon-Mi,Lee, Minhee,Lee, So Young,Lee, Soo-Min,Kim, Eun Jeong,Kim, Jae Sun,Ann, Jihyae,Lee, Jiyoun,Lee, Jeewoo. "Synthesis and biological evaluation of 3-(2-aminoethyl) uracil derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists". . p. 413 - 424. Retrieved 2018/01/17.