(2-Chlorophenyl)oxirane

Base Information

• Chemical Name: (2-Chlorophenyl)oxirane
• CAS No.: 62717-50-4
• Molecular Formula: C8H7ClO
• Molecular Weight: 154.596
• Hs Code.: 2910900090
• Mol file: 62717-50-4.mol

Synonyms:methyl 2-bromoacrylate;Methyl2-bromopropionate;2-Bromopropionic;DL-2-Methyl broMopropionic;DL-a-bromopropionate;2-BROMOPROPIONATE;methyl2-bromopropanoate;ortho-chlorostyrene oxide;METHYL DL-2-BROMOPROPIONATE;

Chemical Property of (2-Chlorophenyl)oxirane

Chemical Property:

• Boiling Point: 211.8±28.0 °C(Predicted)
• PSA: 12.53000
• Density: 1.283±0.06 g/cm3(Predicted)
• LogP: 2.41130
• Storage Temp.: Refrigerator

Purity/Quality:

96% ^*data from raw suppliers

2-(2-Chlorophenyl)oxirane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(2-Chlorophenyl)oxirane (cas# 62717-50-4) is a compound useful in organic synthesis.

Technology Process of (2-Chlorophenyl)oxirane

There total 36 articles about (2-Chlorophenyl)oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chlorostyrene (2039-87-4,107830-52-4,26125-41-7) → o-chlorostyrene oxide (62717-50-4)

Guidance literature:

With tert.-butylhydroperoxide; 2C₁₃H₁₀N₃O₂^(1-)*MoO₂⁽²⁺⁾; In methanol; dichloromethane; for 1h; Reagent/catalyst; Catalytic behavior;

DOI:10.1080/00958972.2013.816416

Reference yield: 93.0%

trimethylsulphonium iodide (2181-42-2) + 2-chloro-benzaldehyde (89-98-5) → o-chlorostyrene oxide (62717-50-4)

Guidance literature:

trimethylsulphonium iodide; With sodium hydroxide; In water; for 0.166667h;

2-chloro-benzaldehyde; With 1,3-bis[3,5-bis(trifluoromethyl)phenyl]urea; In dichloromethane; water; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1039/b719767e

Reference yield: 86.0%

2-chloro-benzaldehyde (89-98-5) + methyl trifluoromethanesulfonate (333-27-7) → o-chlorostyrene oxide (62717-50-4)

Guidance literature:

2-chloro-benzaldehyde; methyl trifluoromethanesulfonate; With thiophene; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In dichloromethane; at 20 ℃; for 0.416667h; Inert atmosphere;

With 1-tert-butyl-2,2,4,4,4-pentakis(dimethylamino)-2Λ⁵,4Λ⁵-catenadi(phosphazene); In tetrahydrofuran; dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol902816w

upstream raw materials:

2-Bromo-1-(2-chlorophenyl)ethan-1-ol

2-chloro-benzaldehyde

S,S,S-trimethylsulfonium methanesulfonate

2-chlorostyrene

Downstream raw materials:

(R)-(-)-2-(2-chlorophenyl)oxirane

4-Phenyl-1,3-dioxolan-2-one

(S)-(+)-2-(2-chlorophenyl)oxirane

(R)-(2-chlorophenyl)-1,2-ethanediol

Refernces

• 1、 -. "Clomaalin hapten and artificial antigen as well as preparation method and application thereof". Paragraph 0069-0071. . Retrieved 2021/09/11.
• 2、 Xiao, Hu,Dong, Shuang,Liu, Yan,Pei, Xiao-Qiong,Lin, Hui,Wu, Zhong-Liu. "A new clade of styrene monooxygenases for (R)-selective epoxidation". . p. 2195 - 2201. Retrieved 2021/04/12.