2-Methyl-1,2,3,4-tetrahydroquinoxaline

Base Information

• Chemical Name: 2-Methyl-1,2,3,4-tetrahydroquinoxaline
• CAS No.: 6640-55-7
• Molecular Formula: C₉H₁₂N₂
• Molecular Weight: 148.208
• Hs Code.: 2933990090
• Mol file: 6640-55-7.mol

Synonyms:(RS)-1,2,3,4-Tetrahydro-2-methylquinoxaline;2-Methyl-1,2,3,4-tetrahydroquinoxaline; NSC 48966

Chemical Property of 2-Methyl-1,2,3,4-tetrahydroquinoxaline

Chemical Property:

• Vapor Pressure: 0.00331mmHg at 25°C
• Melting Point: 64-69℃
• Boiling Point: 282.7°C at 760 mmHg
• Flash Point: 169.6°C
• PSA: 24.06000
• Density: 0.999g/cm³
• LogP: 2.18850
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Methyl-1,2,3,4-tetrahydroquinoxaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methyl-1,2,3,4-tetrahydroquinoxaline

There total 20 articles about 2-Methyl-1,2,3,4-tetrahydroquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-methylquinoxaline (7251-61-8) → 2-methyl-1,2,3,4-tetrahydroquinoxaline (6640-55-7,24463-30-7,24463-31-8,49849-47-0)

Guidance literature:

With lithium borohydride; methyl iodide; In tetrahydrofuran; at 20 ℃; for 0.25h;

DOI:10.1002/jhet.5570420546

Reference yield: 95.0%

3-methyl-2-oxo-1,2-dihydroquinoxaline (14003-34-0) → 2-methyl-1,2,3,4-tetrahydroquinoxaline (6640-55-7,24463-30-7,24463-31-8,49849-47-0)

Guidance literature:

With tris(pentafluorophenyl)borate; In toluene; at 110 ℃; for 16h;

DOI:10.1039/c7gc03095a

Reference yield: 91.0%

pyruvic acid methyl ester (600-22-6) + 1,2-diamino-benzene (95-54-5) → 2-methyl-1,2,3,4-tetrahydroquinoxaline (6640-55-7,24463-30-7,24463-31-8,49849-47-0)

Guidance literature:

With tris(pentafluorophenyl)borate; In toluene; at 110 ℃; for 16h; Solvent; Temperature; Catalytic behavior;

DOI:10.1039/c7gc03095a

upstream raw materials:

2-methylquinoxaline

2-chloro-3-methylquinoxaline

1-(2-Aminophenyl)-4,5-dihydro-4-methyl-5-morpholino-1,2,3-triazole

3-methyl-2-oxo-1,2-dihydroquinoxaline

Downstream raw materials:

2-<(E)-2-Phenylethenyl>chinoxalin

2-phenethylquinoxaline

2-methylquinoxaline

1-nitroso-2,4-dimetil-1,2,3,4-tetraidrochinossalina

Refernces

• 1、 Zhou, Chao-Zheng,Zhao, Yu-Rou,Tan, Fang-Fang,Guo, Yan-Jun,Li, Yang. "Utilization of renewable formic acid from lignocellulosic biomass for the selective hydrogenation and/or N-methylation". . p. 4724 - 4728. Retrieved 2021/09/06.
• 2、 Lei, Hong-Xu,Zhang, KaiLi,Qin, Yu-Xi,Dong, Rong-Jian,Chen, De-Zhan,Zhou, HaiFeng,Sheng, Xie-Huang. "A quantum-chemical approach to develop tetrahydroquinoxaline as potent ferroptosis inhibitors". . . Retrieved 2020/11/10.