Methanesulfonic acid, trifluoro-, 2-acetylphenyl ester

Base Information

• Chemical Name: Methanesulfonic acid, trifluoro-, 2-acetylphenyl ester
• CAS No.: 129849-05-4
• Molecular Formula: C9H7F3O4S
• Molecular Weight: 268.213
• Mol file: 129849-05-4.mol

Synonyms:

Chemical Property of Methanesulfonic acid, trifluoro-, 2-acetylphenyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid, trifluoro-, 2-acetylphenyl ester

There total 2 articles about Methanesulfonic acid, trifluoro-, 2-acetylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

trifluoromethylsulfonic anhydride (358-23-6) + o-hydroxyacetophenone (118-93-4,104809-67-8) → trifluoromethanesulfonic acid 2-acetylphenyl ester (129849-05-4)

Guidance literature:

With pyridine; at 0 - 20 ℃; for 12h;

DOI:10.1039/c3ob41680a

Reference yield:

Phenyl acetate (122-79-2,34474-31-2) → trifluoromethanesulfonic acid 2-acetylphenyl ester (129849-05-4)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / 1 h / 100 °C

2: 2,6-di-tert-butyl-4-methylpyridine / dichloromethane / 16 h / 20 °C

With aluminum (III) chloride; 2,6-di-tert-butyl-4-methylpyridine; In dichloromethane; 1: |Fries Phenol Ester Rearrangement;

DOI:10.1016/j.bmcl.2013.08.039

Reference yield: 97.0%

trifluoromethanesulfonic acid 2-acetylphenyl ester (129849-05-4) → trifluoro-methanesulfonic acid 1-(2-hydroxy-phenyl)-vinyl ester

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 0.3h;

DOI:10.1021/jo0352023

upstream raw materials:

trifluoromethylsulfonic anhydride

o-hydroxyacetophenone

Phenyl acetate

Downstream raw materials:

o-acetylstyrene

2-acetyl-benzoic acid

1,2-diacetylbenzene

1-(2-ethylphenyl)ethanone

Refernces

• 1、 Ortar, Giorgio,Schiano Moriello, Aniello,Morera, Enrico,Nalli, Marianna,Di Marzo, Vincenzo,De Petrocellis, Luciano. "3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators". . p. 5614 - 5618. Retrieved 2013/10/01.
• 2、 Park, Chan Pil,Nagle, Advait,Cheol, Hwan Yoon,Chen, Chiliu,Kyung, Woon Jung. "Formal aromatic C-H insertion for stereoselective isoquinolinone synthesis and studies on mechanistic insights into the C-C bond formation". supporting information; experimental part. p. 6231 - 6236. Retrieved 2009/12/08.