1-Butoxy-3-methoxypropan-2-OL

Base Information

• Chemical Name: 1-Butoxy-3-methoxypropan-2-OL
• CAS No.: 13021-51-7
• Molecular Formula: C8H18O3
• DSSTox Substance ID: DTXSID30553716
• Nikkaji Number: J1.943.224F
• Mol file: 13021-51-7.mol

Synonyms:1-BUTOXY-3-METHOXYPROPAN-2-OL;13021-51-7;SCHEMBL13191247;DTXSID30553716

Chemical Property of 1-Butoxy-3-methoxypropan-2-OL

Chemical Property:

• Vapor Pressure: 0.013mmHg at 25°C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 162.125594432
• Heavy Atom Count: 11
• Complexity: 75.7

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCOCC(COC)O

Technology Process of 1-Butoxy-3-methoxypropan-2-OL

There total 5 articles about 1-Butoxy-3-methoxypropan-2-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

glycidyl n-butyl ether (2426-08-6) + methanol (67-56-1) → 1-butoxy-3-methoxypropan-2-ol (13021-51-7)

Guidance literature:

With sulfuric acid; silica gel; at 20 ℃; for 0.5h;

DOI:10.1080/10426500490459722

Reference yield:

glycidyl n-butyl ether (2426-08-6) + sodium methylate (124-41-4) → 1-butoxy-3-methoxypropan-2-ol (13021-51-7)

Guidance literature:

glycidyl n-butyl ether; sodium methylate; In methanol; at 70 ℃; for 0.5h;

With water; In methanol; Cooling with ice;

DOI:10.1039/b923631g

Reference yield:

1-chloro-3-methoxypropan-2-ol (4151-97-7) + butan-1-ol (71-36-3) → 1-butoxy-3-methoxypropan-2-ol (13021-51-7)

Guidance literature:

With potassium hydroxide; at 65 ℃;

DOI:10.1021/acs.oprd.9b00411

upstream raw materials:

glycidyl n-butyl ether

methanol

sodium methylate

1-chloro-3-methoxypropan-2-ol

Refernces

• 1、 Deshpande, Nitish,Parulkar, Aamena,Joshi, Rutuja,Diep, Brian,Kulkarni, Ambarish,Brunelli, Nicholas A.. "Epoxide ring opening with alcohols using heterogeneous Lewis acid catalysts: Regioselectivity and mechanism". . p. 46 - 54. Retrieved 2019.
• 2、 -. "PERFUMES IN THE FORM OF AQUEOUS MICROEMULSIONS". Paragraph 0104-0107. . Retrieved 2020/07/04.
• 3、 Leal-Duaso, Alejandro,Gracia-Barberán, Sara,Mayoral, José A.,Garciá, José I.,Pires, Elisabet. "Readily Scalable Methodology for the Synthesis of Nonsymmetric Glyceryl Diethers by a Tandem Acid-/Base-Catalyzed Process". . p. 154 - 162. Retrieved 2020/02/04.